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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Autoimmun. 2017 Feb 24;80:65–76. doi: 10.1016/j.jaut.2017.02.006

Fig. 4. Hyperosmolarity-activated caspse-8 reciprocally regulates NLRP3/NLRP6 mediated inflammasomes in HCECs.

Fig. 4

(A) Immunofluorescent staining results showed the increased number of caspase-8, NLRP3 or ASC positive cells with decreased number of NLRP6 positive cells in HCECs at 450mOsM, which was completely reversed by 20μM C8-Inh, but partly by P3-Inh. (B) Double Immunofluorescent staining showed that caspase-8 involved in NLRP3/ASC/caspase-8 inflammasomes in HCECs exposed to 450mOsM medium, which was completely reversed by 20μM C8-Inh, but partly by P3-Inh. Data shown are representative of three or more independent experiments.