Skip to main content
. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Trends Genet. 2017 Mar 30;33(5):303–321. doi: 10.1016/j.tig.2017.03.002

Figure 3. Regulation of CRTC2 nuclear localization.

Figure 3

CRTC2 can be phosphorylated by multiple LKB1 regulated kinases (AMPK, SIK1/2/3, MARK2). The phosphorylated form of CRTC2 is bound by 14-3-3 proteins and sequestered in the cytoplasm where is it inactive. Dephosphorylation of CRTC1 by phosphatases such as calcineurin releases 14-3-3 binding and induces CRTC2 nuclear translation. In the nucleus, CRTC2 binds to bZIP transcription factors to promote transcription.