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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Trends Genet. 2017 Mar 30;33(5):303–321. doi: 10.1016/j.tig.2017.03.002

Figure 5, Key Figure.

Figure 5, Key Figure

Physiological and cellular processes modulated by CRTCs.

Inner circle lists the proteins known to interact directly with at least one CRTC family member. Outer circle represents the physiological and cellular processes specifically controlled by the interaction between CRTC and its interacting partner. CRTC can either interact with a unique partner to modulate a unique pathway (eg: CRTC-Sec31 influencing lipogenesis), or multiple pathways (eg: CRTC-CREB acting on splicing, autophagy, etc.), or can interact with multiple proteins to act on the same physiological process (eg: CRTC-CREB or CRTC-CBP modulating gluconeogenesis).