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. 2017 Jul 15;144(14):2618–2628. doi: 10.1242/dev.149708

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© 2017. Published by The Company of Biologists Ltd

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Fig. 1. — Loss of Sin3a leads to specific lung developmental defects. (A) Hematoxylin and Eosin staining of thoracic transverse section of neonatal (P0) Sin3a^f/f (Shh^Cre/+;Sin3a^flox/flox;Rosa-mTmG) mutant and Sin3a^f/+ (Shh^Cre/+;Sin3a^flox/+;Rosa-mTmG) littermate. (B-F) Whole-mount fluorescence imaging of whole embryo (B), lung and gastrointestinal tract (C) and lung (D-F) of Sin3a^f/f mutants and Sin3a^f/+ littermates at E12.5 and E14.5. Domain of Cre activity is indicated by GFP expression (green). Arrowheads in E indicate disruption of tracheal integrity.