Fig. 2.

Endodermal Sin3a is required for activation of gene expression programs associated with epithelial cell fate and lung development. (A) Heatmap of the top 100 differentially expressed genes from RNA-seq. (B,E) Pie charts of downregulated (B) and upregulated (E) genes mapped to fetal lung cells using LungGENS database. (C,F) Normalized fold change of RNA-Seq gene expression values for selected downregulated (C) and upregulated (F) genes. (D) Top GO terms for genes downregulated more than twofold. Significance determined by Cufflinks software; ***P<0.001,****P<0.0001.