Figure 1.
(a) Domains of CtBP1- Role, functions and post-translational modification sites. R, E and H signify the catalytic triad within the CtBP dehydrogenase domain (b) Graphical representation of CtBP mediated co-repression, where CtBP nucleates a complex that bridges chromatin modifiers (including histone deacteylases [HDAC] and histone methyltransferases [HMT]) to specific DNA sites recognized by a DNA-interacting protein (DNA-IP) that encodes a PxDLS domain.