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. 2017 May 22;18(6):379–391. doi: 10.1080/15384047.2017.1323586

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© 2017 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — APC-dependent role of CtBP in the Wnt/ β-catenin pathway. In the presence of normal APC (APC-FL; left), CtBP participates in the destruction complex to sequester β-catenin (B-cat) and target it for proteasomal degradation. With mutant APC (APC-Mut/trunc; right), CtBP facilitates oligomerization and cytoplasmic sequestration of APC, promoting β-catenin release to the nucleus to induce downstream TCF/LEF mediated cell signaling, in which CtBP also plays a direct role as a coactivator at TCF target genes.^75,76