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. 2017 May 26;30(8):1152–1169. doi: 10.1038/modpathol.2017.38

Table 2. Associations between infrequently expressed miRNAs in colorectal cancer and TP53 mutations.

miRNA Not-mutated
 TP53-Mutated
   P-value
  N % N % OR (95% CI) unadjusted Q value
hsa-miR-1207-3p                
 Down-regulateda 68 7.1 80 9.3 1.31 (0.94, 1.84) 0.115 0.919
 Referent 849 89.1 773 89.5 1.00      
 Up-regulated 36 3.8 11 1.3 0.35 (0.17, 0.69) 0.002 0.030
                 
hsa-miR-1243                
 Down-regulated 161 16.9 140 16.2 0.92 (0.72, 1.18) 0.519 0.981
 Referent 710 74.5 677 78.4 1.00      
 Up-Regulated 82 8.6 47 5.4 0.60 (0.41, 0.88) 0.008 0.042
                 
hsa-miR-1296                
 Down-regulated 51 5.4 44 5.1 0.95 (0.63, 1.45) 0.824 0.981
 Referent 878 92.1 777 89.9 1.00      
 Up-Regulated 24 2.5 43 5.0 2.02 (1.22, 3.37) 0.007 0.039
                 
hsa-miR-133a                
 Down-regulated 35 3.7 38 4.4 1.19 (0.74, 1.91) 0.469 0.981
 Referent 910 95.5 805 93.2 1.00      
 Up-Regulated 8 0.8 21 2.4 2.99 (1.32, 6.80) 0.009 0.043
                 
hsa-miR-133b                
 Down-regulated 483 50.7 458 53.0 1.17 (0.96, 1.43) 0.116 0.919
 Referent 415 43.5 326 37.7 1.00      
 Up-Regulated 55 5.8 80 9.3 1.85 (1.27, 2.69) 0.001 0.030
                 
hsa-miR-151a-3p                
 Down-regulated 43 4.5 34 3.9 1.03 (0.64, 1.65) 0.900 0.982
 Referent 583 61.2 430 49.8 1.00      
 Up-Regulated 327 34.3 400 46.3 1.63 (1.35, 1.98) <0.0001 0.030
                 
hsa-miR-184                
 Down-regulated 197 20.7 204 23.6 1.29 (1.02, 1.62) 0.031 0.919
 Referent 623 65.4 511 59.1 1.00      
 Up-Regulated 133 14.0 149 17.2 1.40 (1.08, 1.82) 0.012 0.047
                 
hsa-miR-192-3p                
 Down-regulated 222 23.3 189 21.9 0.97 (0.77, 1.22) 0.793 0.981
 Referent 650 68.2 555 64.2 1.00      
 Up-Regulated 81 8.5 120 13.9 1.73 (1.27, 2.34) 0.000 0.030
                 
hsa-miR-19a-3p                
 Down-regulated 11 1.2 8 0.9 0.91 (0.36, 2.27) 0.836 0.981
 Referent 745 78.2 597 69.1 1.00      
 Up-Regulated 197 20.7 259 30.0 1.64 (1.33, 2.04) <0.0001 0.030
                 
hsa-miR-224-5p                
 Down-regulated 24 2.5 14 1.6 0.93 (0.47, 1.84) 0.843 0.981
 Referent 364 38.2 222 25.7 1.00      
 Up-Regulated 565 59.3 628 72.7 1.79 (1.46, 2.19) <0.0001 0.030
                 
hsa-miR-3190-5p                
 Down-regulated 11 1.2 11 1.3 1.14 (0.49, 2.65) 0.758 0.981
 Referent 937 98.3 837 96.9 1.00      
 Up-Regulated 5 0.5 16 1.9 3.62 (1.32, 9.93) 0.013 0.047
                 
hsa-miR-31-5p                
 Down-regulated 14 1.5 11 1.3 0.83 (0.37, 1.83) 0.637 0.981
 Referent 775 81.3 762 88.2 1.00      
 Up-Regulated 164 17.2 91 10.5 0.57 (0.43, 0.75) <.0001 0.030
                 
hsa-miR-3607-3p                
 Down-regulated 53 5.6 63 7.3 1.36 (0.93, 1.99) 0.111 0.919
 Referent 835 87.6 715 82.8 1.00      
 Up-Regulated 65 6.8 86 10.0 1.52 (1.09, 2.14) 0.014 0.0495
                 
hsa-miR-3609                
 Down-regulated 193 20.3 142 16.4 0.86 (0.67, 1.11) 0.247 0.981
 Referent 588 61.7 492 56.9 1.00      
 Up-Regulated 172 18.0 230 26.6 1.60 (1.27, 2.02) <0.0001 0.030
                 
hsa-miR-3615                
 Down-regulated 207 21.7 201 23.3 1.04 (0.83, 1.31) 0.708 0.981
 Referent 640 67.2 602 69.7 1.00      
 Up-Regulated 106 11.1 61 7.1 0.63 (0.45, 0.88) 0.007 0.039
                 
hsa-miR-3622b-3p                
 Down-regulated 22 2.3 26 3.0 1.48 (0.83, 2.64) 0.186 0.966
 Referent 746 78.3 615 71.2 1.00      
 Up-Regulated 185 19.4 223 25.8 1.48 (1.19, 1.85) 0.001 0.030
                 
hsa-miR-362-5p                
 Down-regulated 26 2.7 13 1.5 0.60 (0.31, 1.18) 0.141 0.919
 Referent 730 76.6 587 67.9 1.00      
 Up-Regulated 197 20.7 264 30.6 1.66 (1.34, 2.06) <0.0001 0.030
                 
hsa-miR-3687                
 Down-regulated 12 1.3 14 1.6 1.42 (0.65, 3.11) 0.376 0.981
 Referent 726 76.2 580 67.1 1.00      
 Up-Regulated 215 22.6 270 31.3 1.57 (1.27, 1.93) <0.0001 0.030
                 
hsa-miR-374a-5p                
 Down-regulated 15 1.6 7 0.8 0.55 (0.22, 1.35) 0.189 0.966
 Referent 781 82.0 664 76.9 1.00      
 Up-Regulated 157 16.5 193 22.3 1.43 (1.13, 1.81) 0.003 0.031
                 
hsa-miR-374b-5p                
 Down-regulated 31 3.3 16 1.9 0.62 (0.34, 1.15) 0.131 0.919
 Referent 711 74.6 563 65.2 1.00      
 Up-Regulated 211 22.1 285 33.0 1.68 (1.36, 2.08) <0.0001 0.030
                 
hsa-miR-424-5p                
 Down-regulated 17 1.8 14 1.6 0.98 (0.48, 2.00) 0.950 0.997
 Referent 701 73.6 572 66.2 1.00      
 Up-Regulated 235 24.7 278 32.2 1.41 (1.15, 1.74) 0.001 0.030
                 
hsa-miR-4251                
 Down-regulated 72 7.6 76 8.8 1.35 (0.95, 1.90) 0.090 0.919
 Referent 639 67.1 514 59.5 1.00      
 Up-Regulated 242 25.4 274 31.7 1.42 (1.15, 1.75) 0.001 0.030
                 
hsa-miR-4296                
 Down-regulated 79 8.3 68 7.9 1.01 (0.71, 1.42) 0.975 0.997
 Referent 728 76.4 625 72.3 1.00      
 Up-Regulated 146 15.3 171 19.8 1.38 (1.08, 1.76) 0.011 0.047
                 
hsa-miR-4421                
 Down-regulated 216 22.7 179 20.7 0.95 (0.75, 1.19) 0.640 0.981
 Referent 664 69.7 589 68.2 1.00      
 Up-Regulated 73 7.7 96 11.1 1.51 (1.09, 2.09) 0.013 0.047
                 
hsa-miR-4654                
 Down-regulated 169 17.7 163 18.9 1.21 (0.95, 1.56) 0.128 0.919
 Referent 569 59.7 450 52.1 1.00      
 Up-Regulated 215 22.6 251 29.1 1.48 (1.19, 1.85) 0.001 0.030
                 
hsa-miR-4695-3p                
 Down-regulated 25 2.6 25 2.9 1.14 (0.65, 2.01) 0.644 0.981
 Referent 912 95.7 808 93.5 1.00      
 Up-Regulated 16 1.7 31 3.6 2.20 (1.19, 4.06) 0.012 0.047
                 
hsa-miR-4711-5p                
 Down-regulated 22 2.3 19 2.2 0.94 (0.50, 1.75) 0.849 0.981
 Referent 905 95.0 840 97.2 1.00      
 Up-Regulated 26 2.7 5 0.6 0.22 (0.08, 0.57) 0.002 0.030
                 
hsa-miR-484                
 Down-regulated 106 11.1 86 10.0 0.91 (0.67, 1.24) 0.550 0.981
 Referent 763 80.1 659 76.3 1.00      
 Up-Regulated 84 8.8 119 13.8 1.59 (1.18, 2.15) 0.002 0.030
                 
hsa-miR-5095                
 Down-regulated 134 14.1 105 12.2 0.89 (0.67, 1.17) 0.401 0.981
 Referent 710 74.5 624 72.2 1.00      
 Up-Regulated 109 11.4 135 15.6 1.42 (1.08, 1.87) 0.013 0.047
                 
hsa-miR-532-3p                
 Down-regulated 61 6.4 44 5.1 0.83 (0.55, 1.25) 0.368 0.981
 Referent 739 77.5 622 72.0 1.00      
 Up-Regulated 153 16.1 198 22.9 1.51 (1.19, 1.91) 0.001 0.030
                 
hsa-miR-532-5p                
 Down-regulated 48 5.0 22 2.5 0.60 (0.35, 1.00) 0.052 0.919
 Referent 655 68.7 482 55.8 1.00      
 Up-Regulated 250 26.2 360 41.7 1.94 (1.59, 2.37) <.0001 0.030
                 
hsa-miR-5685                
 Down-regulated 184 19.3 173 20.0 1.01 (0.80, 1.28) 0.922 0.993
 Referent 683 71.7 645 74.7 1.00      
 Up-Regulated 86 9.0 46 5.3 0.57 (0.39, 0.83) 0.003 0.031
                 
hsa-miR-625-5p                
 Down-regulated 17 1.8 17 2.0 1.09 (0.55, 2.15) 0.806 0.981
 Referent 898 94.2 831 96.2 1.00      
 Up-Regulated 38 4.0 16 1.9 0.47 (0.26, 0.84) 0.012 0.047
                 
hsa-miR-652-3p                
 Down-regulated 39 4.1 25 2.9 0.72 (0.43, 1.20) 0.209 0.966
 Referent 824 86.5 702 81.3 1.00      
 Up-Regulated 90 9.4 137 15.9 1.75 (1.32, 2.33) 0.000 0.030
                 
hsa-miR-664a-3p                
 Down-regulated 201 21.1 186 21.5 1.13 (0.89, 1.43) 0.314 0.981
 Referent 569 59.7 455 52.7 1.00      
 Up-Regulated 183 19.2 223 25.8 1.50 (1.19, 1.89) 0.001 0.030
                 
hsa-miR-7-5p                
 Down-regulated 14 1.5 10 1.2 0.98 (0.43, 2.22) 0.957 0.997
 Referent 580 60.9 421 48.7 1.00      
 Up-Regulated 359 37.7 433 50.1 1.67 (1.38, 2.01) <0.0001 0.030
                 
hsa-miR-98-5p                
 Down-regulated 26 2.7 18 2.1 0.82 (0.44, 1.51) 0.522 0.981
 Referent 727 76.3 592 68.5 1.00      
 Up-Regulated 200 21.0 254 29.4 1.54 (1.24, 1.91) <0.0001 0.030
a

Down-regulated have differential expression <−1.77; referent has differential expression between -1.77, 2.08; up-regulated has differential expression >2.08.