Table 3. Overall associations between differential miRNA expression in infrequently expressed miRNA and CIMP High tumors.

	CIMP-Low/Negative		CIMP-High
miRNA	N	%	N	%	OR	(95% CI)	P value	Q value
hsa-miR-151a-3p
Down-regulateda	45	3.4	20	5.6	1.46	(0.84, 2.56)	0.18	0.727
Referent	696	53.0	221	62.4	1.00
Up-Regulated	571	43.5	113	31.9	0.64	(0.50, 0.83)	0.007	0.033
hsa-miR-1915-5p
Down-regulated	109	8.3	24	6.8	0.83	(0.52, 1.31)	0.42	0.773
Referent	1138	86.7	298	84.2	1.00
Up-Regulated	65	5.0	32	9.0	1.90	(1.21, 2.98)	0.005	0.036
hsa-miR-193a-3p
Down-regulated	24	1.8	8	2.3	1.06	(0.46, 2.42)	0.90	0.895
Referent	908	69.2	273	77.1	1.00
Up-Regulated	380	29.0	73	20.6	0.63	(0.47, 0.84)	0.002	0.033
hsa-miR-199b-5p
Down-regulated	80	6.1	29	8.2	1.25	(0.79, 1.99)	0.34	0.753
Referent	804	61.3	247	69.8	1.00
Up-Regulated	428	32.6	78	22.0	0.61	(0.46, 0.81)	0.002	0.033
hsa-miR-19a-3p
Down-regulated	14	1.1	5	1.4	1.21	(0.42, 3.43)	0.73	0.803
Referent	924	70.4	281	79.4	1.00
Up-Regulated	374	28.5	68	19.2	0.59	(0.44, 0.79)	0.0005	0.033
hsa-miR-2110
Down-regulated	68	5.2	17	4.8	0.94	(0.54, 1.63)	0.83	0.826
Referent	1212	92.4	317	89.5	1.00
Up-Regulated	32	2.4	20	5.6	2.48	(1.39, 4.44)	0.002	0.033
hsa-miR-224-5p
Down-regulated	27	2.1	5	1.4	0.38	(0.14, 1.02)	0.05	0.436
Referent	330	25.2	174	49.2	1.00
Up-Regulated	955	72.8	175	49.4	0.35	(0.27, 0.45)	<0.0001	0.033
hsa-miR-30e-5p
Down-regulated	445	33.9	140	39.5	1.14	(0.88, 1.48)	0.31	0.753
Referent	644	49.1	177	50.0	1.00
Up-Regulated	223	17.0	37	10.5	0.61	(0.41, 0.89)	0.01	0.041
hsa-miR-31-5p
Down-regulated	17	1.3	7	2.0	1.80	(0.73, 4.44)	0.20	0.727
Referent	1176	89.6	244	68.9	1.00
Up-Regulated	119	9.1	103	29.1	4.17	(3.08, 5.65)	<0.0001	0.033
hsa-miR-3609
Down-regulated	219	16.7	83	23.4	1.34	(0.99, 1.80)	0.05	0.436
Referent	757	57.7	228	64.4	1.00
Up-Regulated	336	25.6	43	12.1	0.43	(0.30, 0.61)	<0.0001	0.033
hsa-miR-3615
Down-regulated	295	22.5	88	24.9	1.22	(0.92, 1.62)	0.17	0.727
Referent	904	68.9	220	62.1	1.00
Up-Regulated	113	8.6	46	13.0	1.65	(1.13, 2.41)	0.01	0.038
hsa-miR-362-5p
Down-regulated	27	2.1	5	1.4	0.63	(0.24, 1.67)	0.35	0.753
Referent	917	69.9	283	79.9	1.00
Up-Regulated	368	28.0	66	18.6	0.58	(0.43, 0.79)	0.0004	0.033
hsa-miR-3687
Down-regulated	20	1.5	5	1.4	0.95	(0.35, 2.58)	0.92	0.916
Referent	908	69.2	273	77.1	1.00
Up-Regulated	384	29.3	76	21.5	0.66	(0.50, 0.88)	0.004	0.035
hsa-miR-374a-5p
Down-regulated	14	1.1	7	2.0	1.65	(0.65, 4.19)	0.29	0.753
Referent	1003	76.4	305	86.2	1.00
Up-Regulated	295	22.5	42	11.9	0.48	(0.34, 0.68)	<0.0001	0.033
hsa-miR-374b-5p
Down-regulated	27	2.1	15	4.2	1.96	(1.01, 3.80)	0.05	0.436
Referent	878	66.9	272	76.8	1.00
Up-Regulated	407	31.0	67	18.9	0.54	(0.40, 0.72)	<0.0001	0.033
hsa-miR-3938
Down-regulated	44	3.4	12	3.4	1.03	(0.54, 2.00)	0.92	0.919
Referent	1239	94.4	324	91.5	1.00
Up-Regulated	29	2.2	18	5.1	2.51	(1.36, 4.65)	0.003	0.033
hsa-miR-3944-5p
Down-regulated	308	23.5	68	19.2	0.85	(0.62, 1.15)	0.29	0.753
Referent	790	60.2	206	58.2	1.00
Up-Regulated	214	16.3	80	22.6	1.47	(1.08, 1.99)	0.01	0.044
hsa-miR-424-5p
Down-regulated	21	1.6	8	2.3	1.33	(0.58, 3.07)	0.50	0.803
Referent	875	66.7	280	79.1	1.00
Up-Regulated	416	31.7	66	18.6	0.52	(0.39, 0.70)	<.0001	0.033
hsa-miR-4492
Down-regulated	74	5.6	18	5.1	0.87	(0.51, 1.49)	0.62	0.803
Referent	1190	90.7	309	87.3	1.00
Up-Regulated	48	3.7	27	7.6	2.18	(1.33, 3.59)	0.002	0.033
hsa-miR-4533
Down-regulated	169	12.9	61	17.2	1.52	(1.09, 2.11)	0.01	0.184
Referent	1036	79.0	243	68.6	1.00
Up-Regulated	107	8.2	50	14.1	2.07	(1.43, 3.01)	0.0001	0.033
hsa-miR-4709-3p
Down-regulated	122	9.3	32	9.0	0.99	(0.65, 1.50)	0.96	0.965
Referent	1045	79.6	265	74.9	1.00
Up-Regulated	145	11.1	57	16.1	1.55	(1.10, 2.18)	0.01	0.041
hsa-miR-4722-5p
Down-regulated	437	33.3	107	30.2	0.96	(0.73, 1.26)	0.75	0.803
Referent	683	52.1	173	48.9	1.00
Up-Regulated	192	14.6	74	20.9	1.53	(1.11, 2.10)	0.01	0.038
hsa-miR-484
Down-regulated	131	10.0	46	13.0	1.26	(0.86, 1.83)	0.23	0.753
Referent	1013	77.2	283	79.9	1.00
Up-Regulated	168	12.8	25	7.1	0.55	(0.35, 0.85)	0.008	0.038
hsa-miR-513a-3p
Down-regulated	59	4.5	18	5.1	1.16	(0.67, 2.01)	0.58	0.803
Referent	1229	93.7	321	90.7	1.00
Up-Regulated	24	1.8	15	4.2	2.42	(1.24, 4.74)	0.01	0.038
hsa-miR-532-3p
Down-regulated	70	5.3	20	5.6	0.93	(0.55, 1.57)	0.77	0.803
Referent	956	72.9	291	82.2	1.00
Up-Regulated	286	21.8	43	12.1	0.51	(0.36, 0.72)	0.0001	0.033
hsa-miR-532-5p
Down-regulated	38	2.9	17	4.8	1.38	(0.76, 2.53)	0.29	0.753
Referent	774	59.0	258	72.9	1.00
Up-Regulated	500	38.1	79	22.3	0.47	(0.36, 0.63)	<0.0001	0.033
hsa-miR-5685
Down-regulated	265	20.2	63	17.8	0.89	(0.65, 1.22)	0.48	0.798
Referent	969	73.9	252	71.2	1.00
Up-Regulated	78	5.9	39	11.0	1.96	(1.29, 2.97)	0.001	0.033
hsa-miR-590-5p
Down-regulated	173	13.2	61	17.2	1.28	(0.92, 1.77)	0.14	0.727
Referent	983	74.9	269	76.0	1.00
Up-Regulated	156	11.9	24	6.8	0.55	(0.35, 0.87)	0.01	0.038
hsa-miR-6071
Down-regulated	151	11.5	37	10.5	0.89	(0.60, 1.30)	0.54	0.803
Referent	1135	86.5	301	85.0	1.00
Up-Regulated	26	2.0	16	4.5	2.49	(1.31, 4.75)	0.006	0.036
hsa-miR-625-5p
Down-regulated	26	2.0	7	2.0	1.07	(0.46, 2.51)	0.88	0.876
Referent	1261	96.1	323	91.2	1.00
Up-Regulated	25	1.9	24	6.8	3.55	(1.98, 6.37)	<0.0001	0.033
hsa-miR-652-3p
Down-regulated	41	3.1	15	4.2	1.35	(0.72, 2.51)	0.35	0.753
Referent	1085	82.7	310	87.6	1.00
Up-Regulated	186	14.2	29	8.2	0.56	(0.37, 0.86)	0.007	0.038
hsa-miR-664a-3p
Down-regulated	301	22.9	63	17.8	0.64	(0.47, 0.87)	<0.0001	0.184
Referent	687	52.4	234	66.1	1.00
Up-Regulated	324	24.7	57	16.1	0.52	(0.38, 0.72)	<0.0001	0.033
hsa-miR-873-3p
Down-regulated	42	3.2	10	2.8	0.94	(0.46, 1.90)	0.86	0.858
Referent	1226	93.4	318	89.8	1.00
Up-Regulated	44	3.4	26	7.3	2.17	(1.30, 3.61)	0.001	0.033
hsa-miR-98-5p
Down-regulated	25	1.9	16	4.5	2.44	(1.26, 4.72)	0.008	0.184
Referent	927	70.7	269	76.0	1.00
Up-Regulated	360	27.4	69	19.5	0.68	(0.51, 0.91)	0.01	0.038

^aDown-regulated have differential expression <−1.77; referent has differential expression between −1.77, 2.08; up-regulated has differential expression >2.08.