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. 2017 May 26;30(8):1152–1169. doi: 10.1038/modpathol.2017.38

Table 4. Overall associations between differential miRNA expression in infrequently expressed miRNA and MSI tumors.

miRNA MSS
 MSI
     P-value
  N % N % OR (95% CI) unadjusted Q value
hsa-miR-1207-3p                
 Down-regulated 140 8.3 13 7.6 0.96 (0.53, 1.75) 0.90 0.90
 Referent 1512 89.6 145 85.3 1.00      
 Up-Regulated 35 2.1 12 7.1 3.28 (1.65, 6.53) 0.0007 0.04
                 
hsa-miR-133b                
 Down-regulated 891 52.8 68 40.0 0.57 (0.40, 0.79) 0.001 0.19
 Referent 664 39.4 96 56.5 1.00      
 Up-Regulated 132 7.8 6 3.5 0.31 (0.13, 0.74) 0.08 0.04
                 
hsa-miR-151a-3p                
 Down-regulated 70 4.1 8 4.7 0.85 (0.39, 1.82) 0.67 0.71
 Referent 896 53.1 138 81.2 1.00      
 Up-Regulated 721 42.7 24 14.1 0.22 (0.14, 0.35) <0.0001 0.04
                 
hsa-miR-192-3p                
 Down-regulated 384 22.8 35 20.6 0.86 (0.57, 1.29) 0.47 0.67
 Referent 1107 65.6 128 75.3 1.00      
 Up-Regulated 196 11.6 7 4.1 0.31 (0.14, 0.68) 0.004 0.04
                 
hsa-miR-199b-5p                
 Down-regulated 107 6.3 18 10.6 1.55 (0.89, 2.71) 0.12 0.41
 Referent 1036 61.4 137 80.6 1.00      
 Up-Regulated 544 32.2 15 8.8 0.22 (0.13, 0.38) <0.0001 0.04
                 
hsa-miR-203a                
 Down-regulated 174 10.3 17 10.0 0.70 (0.40, 1.23) 0.21 0.52
 Referent 474 28.1 71 41.8 1.00      
 Up-Regulated 1039 61.6 82 48.2 0.52 (0.37, 0.73) 0.0002 0.04
                 
hsa-miR-28-3p                
 Down-regulated 186 11.0 16 9.4 0.95 (0.55, 1.64) 0.85 0.85
 Referent 1380 81.8 131 77.1 1.00      
 Up-Regulated 121 7.2 23 13.5 1.88 (1.16, 3.06) 0.01 0.04
                 
hsa-miR-30a-5p                
 Down-regulated 604 35.8 64 37.6 1.00 (0.71, 1.41) 1.00 1.00
 Referent 900 53.3 101 59.4 1.00      
 Up-Regulated 183 10.8 5 2.9 0.24 (0.10, 0.61) 0.003 0.04
                 
hsa-miR-30e-5p                
 Down-regulated 578 34.3 70 41.2 1.22 (0.87, 1.71) 0.24 0.53
 Referent 835 49.5 88 51.8 1.00      
 Up-Regulated 274 16.2 12 7.1 0.43 (0.23, 0.80) 0.007 0.04
                 
hsa-miR-3609                
 Down-regulated 289 17.1 52 30.6 1.79 (1.25, 2.58) 0.002 0.19
 Referent 1000 59.3 108 63.5 1.00      
 Up-Regulated 398 23.6 10 5.9 0.23 (0.12, 0.45) <0.0001 0.04
                 
hsa-miR-3615                
 Down-regulated 378 22.4 41 24.1 1.24 (0.84, 1.83) 0.27 0.54
 Referent 1173 69.5 99 58.2 1.00      
 Up-Regulated 136 8.1 30 17.6 2.41 (1.53, 3.79) 0.0001 0.04
                 
hsa-miR-374b-5p                
 Down-regulated 44 2.6 5 2.9 0.97 (0.37, 2.52) 0.95 0.95
 Referent 1146 67.9 160 94.1 1.00      
 Up-Regulated 497 29.5 5 2.9 0.08 (0.03, 0.19) <0.0001 0.04
                 
hsa-miR-3922-5p                
 Down-regulated 192 11.4 8 4.7 0.45 (0.22, 0.94) 0.03 0.28
 Referent 1318 78.1 127 74.7 1.00      
 Up-Regulated 177 10.5 35 20.6 2.07 (1.37, 3.13) 0.0005 0.04
                 
hsa-miR-4492                
 Down-regulated 93 5.5 11 6.5 1.18 (0.61, 2.26) 0.63 0.71
 Referent 1526 90.5 143 84.1 1.00      
 Up-Regulated 68 4.0 16 9.4 2.29 (1.28, 4.10) 0.005 0.04
                 
hsa-miR-4533                
 Down-regulated 231 13.7 27 15.9 1.27 (0.81, 1.98) 0.30 0.56
 Referent 1311 77.7 115 67.6 1.00      
 Up-Regulated 145 8.6 28 16.5 2.09 (1.32, 3.30) 0.002 0.04
                 
hsa-miR-484                
 Down-regulated 182 10.8 11 6.5 0.57 (0.30, 1.08) 0.09 0.38
 Referent 1307 77.5 151 88.8 1.00      
 Up-Regulated 198 11.7 8 4.7 0.37 (0.18, 0.78) 0.008 0.04
                 
hsa-miR-513a-3p                
 Down-regulated 81 4.8 7 4.1 0.84 (0.38, 1.86) 0.67 0.71
 Referent 1575 93.4 154 90.6 1.00      
 Up-Regulated 31 1.8 9 5.3 2.87 (1.32, 6.24) 0.01 0.04
                 
hsa-miR-520d-3p                
 Down-regulated 124 7.4 16 9.4 1.33 (0.76, 2.32) 0.32 0.58
 Referent 1495 88.6 140 82.4 1.00      
 Up-Regulated 68 4.0 14 8.2 2.23 (1.21, 4.11) 0.008 0.04
                 
hsa-miR-532-5p                
 Down-regulated 59 3.5 10 5.9 1.31 (0.64, 2.65) 0.46 0.67
 Referent 1016 60.2 153 90.0 1.00      
 Up-Regulated 612 36.3 7 4.1 0.08 (0.04, 0.17) <0.0001 0.04
                 
hsa-miR-5685                
 Down-regulated 337 20.0 27 15.9 0.83 (0.53, 1.29) 0.41 0.66
 Referent 1243 73.7 116 68.2 1.00      
 Up-Regulated 107 6.3 27 15.9 2.75 (1.71, 4.40) <0.0001 0.04
                 
hsa-miR-664a-3p                
 Down-regulated 360 21.3 28 16.5 0.59 (0.38, 0.91) 0.02 0.26
 Referent 923 54.7 130 76.5 1.00      
 Up-Regulated 404 23.9 12 7.1 0.22 (0.12, 0.40) <0.0001 0.04
                 
hsa-miR-98-5p                
 Down-regulated 40 2.4 6 3.5 1.34 (0.55, 3.26) 0.52 0.67
 Referent 1189 70.5 158 92.9 1.00      
 Up-Regulated 458 27.1 6 3.5 0.10 (0.04, 0.23) <0.0001 0.04
miRNA Microsatellite Stable
 Microsatellite Unstable
     P-value
  N % N % OR (95% CI) unadjusted Q value
hsa-miR-1207-3p                
 Down-regulateda 140 8.3 13 7.6 0.96 (0.53, 1.75) 0.90 0.90
 Referent 1512 89.6 145 85.3 1.00      
 Up-Regulated 35 2.1 12 7.1 3.28 (1.65, 6.53) 0.0007 0.04
                 
hsa-miR-133b                
 Down-regulated 891 52.8 68 40.0 0.57 (0.40, 0.79) 0.001 0.19
 Referent 664 39.4 96 56.5 1.00      
 Up-Regulated 132 7.8 6 3.5 0.31 (0.13, 0.74) 0.08 0.04
                 
hsa-miR-151a-3p                
 Down-regulated 70 4.1 8 4.7 0.85 (0.39, 1.82) 0.67 0.71
 Referent 896 53.1 138 81.2 1.00      
 Up-Regulated 721 42.7 24 14.1 0.22 (0.14, 0.35) <0.0001 0.04
                 
hsa-miR-192-3p                
 Down-regulated 384 22.8 35 20.6 0.86 (0.57, 1.29) 0.47 0.67
 Referent 1107 65.6 128 75.3 1.00      
 Up-Regulated 196 11.6 7 4.1 0.31 (0.14, 0.68) 0.004 0.04
                 
hsa-miR-199b-5p                
 Down-regulated 107 6.3 18 10.6 1.55 (0.89, 2.71) 0.12 0.41
 Referent 1036 61.4 137 80.6 1.00      
 Up-Regulated 544 32.2 15 8.8 0.22 (0.13, 0.38) <0.0001 0.04
                 
hsa-miR-203a                
 Down-regulated 174 10.3 17 10.0 0.70 (0.40, 1.23) 0.21 0.52
 Referent 474 28.1 71 41.8 1.00      
 Up-Regulated 1039 61.6 82 48.2 0.52 (0.37, 0.73) 0.0002 0.04
                 
hsa-miR-28-3p                
 Down-regulated 186 11.0 16 9.4 0.95 (0.55, 1.64) 0.85 0.85
 Referent 1380 81.8 131 77.1 1.00      
 Up-Regulated 121 7.2 23 13.5 1.88 (1.16, 3.06) 0.01 0.04
                 
hsa-miR-30a-5p                
 Down-regulated 604 35.8 64 37.6 1.00 (0.71, 1.41) 1.00 1.00
 Referent 900 53.3 101 59.4 1.00      
 Up-Regulated 183 10.8 5 2.9 0.24 (0.10, 0.61) 0.003 0.04
                 
hsa-miR-30e-5p                
 Down-regulated 578 34.3 70 41.2 1.22 (0.87, 1.71) 0.24 0.53
 Referent 835 49.5 88 51.8 1.00      
 Up-Regulated 274 16.2 12 7.1 0.43 (0.23, 0.80) 0.007 0.04
                 
hsa-miR-3609                
 Down-regulated 289 17.1 52 30.6 1.79 (1.25, 2.58) 0.002 0.19
 Referent 1000 59.3 108 63.5 1.00      
 Up-Regulated 398 23.6 10 5.9 0.23 (0.12, 0.45) <0.0001 0.04
                 
hsa-miR-3615                
 Down-regulated 378 22.4 41 24.1 1.24 (0.84, 1.83) 0.27 0.54
 Referent 1173 69.5 99 58.2 1.00      
 Up-Regulated 136 8.1 30 17.6 2.41 (1.53, 3.79) 0.0001 0.04
                 
hsa-miR-374b-5p                
 Down-regulated 44 2.6 5 2.9 0.97 (0.37, 2.52) 0.95 0.95
 Referent 1146 67.9 160 94.1 1.00      
 Up-Regulated 497 29.5 5 2.9 0.08 (0.03, 0.19) <0.0001 0.04
                 
hsa-miR-3922-5p                
 Down-regulated 192 11.4 8 4.7 0.45 (0.22, 0.94) 0.03 0.28
 Referent 1318 78.1 127 74.7 1.00      
 Up-Regulated 177 10.5 35 20.6 2.07 (1.37, 3.13) 0.0005 0.04
                 
hsa-miR-4492                
 Down-regulated 93 5.5 11 6.5 1.18 (0.61, 2.26) 0.63 0.71
 Referent 1526 90.5 143 84.1 1.00      
 Up-Regulated 68 4.0 16 9.4 2.29 (1.28, 4.10) 0.005 0.04
                 
hsa-miR-4533                
 Down-regulated 231 13.7 27 15.9 1.27 (0.81, 1.98) 0.30 0.56
 Referent 1311 77.7 115 67.6 1.00      
 Up-Regulated 145 8.6 28 16.5 2.09 (1.32, 3.30) 0.002 0.04
                 
hsa-miR-484                
 Down-regulated 182 10.8 11 6.5 0.57 (0.30, 1.08) 0.09 0.38
 Referent 1307 77.5 151 88.8 1.00      
 Up-Regulated 198 11.7 8 4.7 0.37 (0.18, 0.78) 0.008 0.04
                 
hsa-miR-513a-3p                
 Down-regulated 81 4.8 7 4.1 0.84 (0.38, 1.86) 0.67 0.71
 Referent 1575 93.4 154 90.6 1.00      
 Up-Regulated 31 1.8 9 5.3 2.87 (1.32, 6.24) 0.01 0.04
                 
hsa-miR-520d-3p                
 Down-regulated 124 7.4 16 9.4 1.33 (0.76, 2.32) 0.32 0.58
 Referent 1495 88.6 140 82.4 1.00      
 Up-Regulated 68 4.0 14 8.2 2.23 (1.21, 4.11) 0.008 0.04
                 
hsa-miR-532-5p                
 Down-regulated 59 3.5 10 5.9 1.31 (0.64, 2.65) 0.46 0.67
 Referent 1016 60.2 153 90.0 1.00      
 Up-Regulated 612 36.3 7 4.1 0.08 (0.04, 0.17) <0.0001 0.04
                 
hsa-miR-5685                
 Down-regulated 337 20.0 27 15.9 0.83 (0.53, 1.29) 0.41 0.66
 Referent 1243 73.7 116 68.2 1.00      
 Up-Regulated 107 6.3 27 15.9 2.75 (1.71, 4.40) <0.0001 0.04
                 
hsa-miR-664a-3p                
 Down-regulated 360 21.3 28 16.5 0.59 (0.38, 0.91) 0.02 0.26
 Referent 923 54.7 130 76.5 1.00      
 Up-Regulated 404 23.9 12 7.1 0.22 (0.12, 0.40) <0.0001 0.04
                 
hsa-miR-98-5p                
 Down-regulated 40 2.4 6 3.5 1.34 (0.55, 3.26) 0.52 0.67
 Referent 1189 70.5 158 92.9 1.00      
 Up-Regulated 458 27.1 6 3.5 0.10 (0.04, 0.23) <0.0001 0.04
a

Down-regulated have differential expression <-1.77; referent has differential expression between -1.77, 2.08; up-regulated has differential expression >2.08.