Figure 5. Nucleus accumbens dopamine and adenosine receptor expression.
Effects of TAT protein expression on nucleus accumbens dopamine receptor (DRD; A) and adenosine receptor (ADORA; B) expression in response to methamphetamine challenge after exposure to saline (SAL) or methamphetamine (METH). TAT expression, regardless of methamphetamine exposure decreased the expression of all DRDs (A). Methamphetamine exposure, regardless of TAT expression, decreased the expression of the ADORAs (B). TAT expression increased levels of ADORA2A and prevented the reduction of ADORA1 by methamphetamine exposure. Data are expressed as Mean ± SEM (n=5). * p < 0.05, ** p < 0.01, *** p < 0.001