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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Brain Behav Immun. 2017 Apr 27;65:150–160. doi: 10.1016/j.bbi.2017.04.022

Figure 1.

Figure 1

Selection of study subjects from the neuroimaging study of the Washington Heights/Hamilton Heights Inwood Columbia Aging Project (WHICAP).

The study subjects were those participants of the WHICAP imaging sub-study started in 2004. A total of 769 subjects received baseline MRI scans, and among whom we excluded subjects without FreeSurfer data (n=44) and had dementia (n=45). Among the 680 remaining non-demented participants who had baseline MRI data, 306 had repeated structural MRI scan on average 4.5 (SD=0.8) years later. In addition, we also added DTI modality during the follow-up scan for white matter integrity measurement and 237 participants received DTI. For the current study, a total of 508 subjects had CRP, 435 had IL6/ACT measured among those with baseline structural MRI scans, 228 had CRP and 195 had IL6/ACT among those received second structural MRI scans, and 183 had CRP and 154 had IL6/ACT among those who received DTI scan. A total of 357 subjects were included in the analysis after excluding 78 subjects whose IL6 level were out of the measurement range.