Table 1.
Demographic, clinical, and brain morphology characteristics of the WHICAP neuroimaging study participants.
| Number (%) | CRP not measured 172 | CRP measured 508 | Total | p | IL6 or ACT not measured 245 | IL6 or ACT measured 435 | Total | p |
|---|---|---|---|---|---|---|---|---|
| (25%) | (75%) | 680 | (34%) | (66%) | 680 | |||
| Age at scan visit, years, mean(SD) | 81.06 (5.52) | 79.69 (5.56) | 80.04 (5.58) | 0.01 | 80.56 (5.63) | 79.75 (5.54) | 80.04 (5.58) | 0.07 |
| Female, N (%) | 126(73) | 334(66) | 460(68) | 0.07 | 170(69) | 290(67) | 460(68) | 0.47 |
| Race/ethnicity | 0.01 | 0.05 | ||||||
| White | 36(21) | 156(31) | 192(28) | 57(23) | 135(31) | 192(28) | ||
| Blacks | 76(44) | 159(31) | 235(35) | 94(38) | 141(32) | 235(35) | ||
| Hispanics | 56(33) | 184(36) | 240(35) | 92(38) | 148(34) | 240(35) | ||
| Others | 4(2) | 9(2) | 13(2) | 2(0) | 11(0) | 13(0) | ||
| Education, years, mean(SD) | 10.19 (5.03) | 10.93 (4.69) | 10.74 (4.79) | 0.08 | 10.44 (5.08) | 10.92 (4.61) | 10.74 (4.79) | 0.21 |
| Ever smoked, N (%) | 65(41) | 219(47) | 284(46) | 0.22 | 99(45) | 185(46) | 284(46) | 0.93 |
| APOE e4+, N (%) | 40(25) | 127(25) | 167(25) | 0.94 | 66(29) | 101(23) | 167(25) | 0.13 |
| Vascular score, mean(SD) | 1.94 (1.02) | 1.76 (1.00) | 1.81 (1.01) | 0.05 | 1.93 (1.01) | 1.74 (1.00) | 1.81 (1.01) | 0.02 |
| BMI, kg/m2, mean(SD) | 27.29 (5.17) | 27.83 (5.67) | 27.69 (5.55) | 0.28 | 28.12 (5.63) | 27.45 (5.49) | 27.69 (5.55) | 0.14 |
| ICV, mm3, mean(SD) | 1294.61 (149.81) | 1308.97 (158.33) | 1305.34 (156.23) | 0.30 | 1291.58 (159.23) | 1313.09 (154.16) | 1305.34 (156.23) | 0.08 |
| TBV, mm3, mean(SD) | 860.11 (93.31) | 874.53 (102.85) | 870.88 (100.65) | 0.10 | 858.74 (95.76) | 877.72 (102.78) | 870.88 (100.65) | 0.02 |
| Mean CT, mm, mean(SD) | 2.45 (0.12) | 2.46 (0.11) | 2.46 (0.11) | 0.11 | 2.45 (0.12) | 2.46 (0.11) | 2.46 (0.11) | 0.30 |
| Mean FA, mean(SD) | 0.45 (0.02) | 0.45 (0.02) | 0.45 (0.02) | 0.99 | 2.45 (0.12) | 2.46 (0.11) | 2.46 (0.11) | 0.30 |