Table 3.
Divalent ion binding sites in TrpD family
| Ions | Contacts | Reference |
|---|---|---|
| MtbTrpD | ||
| Mg2+‐I | S119, E252, and PRPP | 15 |
| Mg2+‐II | DE(251–252) | |
| SsTrpD | ||
| Mg2+‐I | OH− groups of ribose and pyrophosphate oxygens of PRPP | 7 |
| Mg2+‐II | DE(223–224) | |
| PcTrpD | ||
| Mn2+‐I | S103, E237, and PRPP | 8 |
| Mn2+‐II | DE(236–237) | |
| TkTrpD | ||
| Zn2+‐I | DE(217–218), D78 (subunit A) | This study |
| Zn2+‐II | E118 (subunit A at crystal lattice contacts with E118 from a symmetry molecule) | |
| Zn2+‐III | E235 (subunit B) | |
| Zn2+‐IV | DE(217–218), D78 (subunit B) | |
| Zn2+‐V | E198‐A and E295‐B | |
| Zn2+‐VI | ED(295–296)‐B, E48‐A, E198‐A | |