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Superimposition of ligands (colored sticks) containing a 4-Br substitution in benzene ring A reveal very similar positions of the bromine atom within the binding pocket of PPARγ (green ribbons). A bromine at position 4 of ring A results in higher affinity of the ligand. The presence of a Br atom in this position enables a weak hydrogen bond with the backbone nitrogen of Phe282 (shown as dashes).
