Table 1.
Association between miR-132 Expression and Clinicopathologic Features in Patients with Gastric Cancer
| Parameters | No. of Patients | Change in miR-132 Expressiona | p Valueb | |
|---|---|---|---|---|
| Age (y) | <65 | 130 | 0.70 (0.23–1.39) | 0.036 |
| ≥65 | 71 | 0.40 (0.14–0.96) | ||
| Gender | male | 153 | 0.63 (0.21–1.21) | 0.300 |
| female | 48 | 0.31 (0.14–1.36) | ||
| Location | upper third | 14 | 0.48 (0.26–1.02) | 0.426 |
| middle third | 32 | 0.60 (0.25–2.05) | ||
| lower third | 113 | 0.70(0.17–1.29) | ||
| Gross type | extensive | 42 | 0.41 (0.13–1.03) | 0.571 |
| localized | 29 | 0.47 (0.10–1.66) | ||
| infiltrative | 172 | 0.59 (0.19–1.22) | ||
| Size (maximal diameter) | <5 cm | 89 | 0.87 (0.31–1.43) | 0.001 |
| ≥5 cm | 112 | 0.39 (0.14–0.99) | ||
| Histological type | intestinal | 89 | 0.89 (0.26–1.70) | 0.003 |
| diffuse | 112 | 0.46 (0.16–0.88) | ||
| Depth of invasion (pT) | T1, T2, T3 | 130 | 0.73 (0.24–1.42) | 0.007 |
| T4 | 71 | 0.45 (0.14–0.84) | ||
| Lymph node status (pN) | N0, N1 | 94 | 0.57 (0.20–1.15) | 0.732 |
| N2, N3 | 107 | 0.57 (0.18–1.36) | ||
| Lymph node metastasis | no | 57 | 0.64 (0.20–1.25) | 0.886 |
| yes | 144 | 0.55 (0.18–1.24) | ||
| Lymphatic invasion | no | 154 | 0.63 (0.22–1.26) | 0.236 |
| yes | 47 | 0.45 (0.11–1.01) | ||
| Venous invasion | no | 193 | 0.60 (0.22–1.27) | 0.002 |
| yes | 8 | 0.09 (0.06–0.33) | ||
| Hematogenous metastasisc | no | 181 | 0.64 (0.21–1.34) | 0.022 |
| yes | 20 | 0.32 (0.11–0.57) | ||
| Implantation metastasis | no | 189 | 0.57 (0.18–1.24) | 0.890 |
| yes | 12 | 0.54 (0.22–1.49) | ||
| Pathological stage | I–IIIb | 160 | 0.65 (0.22–1.35) | 0.041 |
| IIIc and IV | 41 | 0.32 (0.17–0.92) |
Median of relative expression, with 25th–75th percentile in parentheses.
Mann-Whitney test (for two groups) or Kruskal-Wallis test (for more than two groups).
Hepatic metastasis, pulmonary metastasis, bone metastasis, and brain metastasis occurrence before the operation or within 5 years after the operation.