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SEPT9 gene. Septins: Multifunctional “scaffolding” proteins that provide structural support during cytokinesis. SEPT9 gene produces septin-9 that appears to act as a tumor suppressor which is active in cells throughout body. In CRC cells: SEPT9 gene is hypermethylated and the DNA is released into peripheral blood. Methylated SEPT9 DNA can be detected by PCR 34.
