Table 2.
Association between the selected single nucleotide polymorphisms and risks of colon cancer, polyp and ulcerative colitis
| Variable (MJ/MI) | Cases/controls | Genetic model | P for Fisher's test |
| rs4809957 A/G | Cancer/1KGeno | AG + GG vs AA | 2.20E-16 |
| G vs A | 2.20E-16 | ||
| GG vs AG + AA | 2.20E-16 | ||
| Polyp/1KGeno | AG + GG vs AA | 2.20E-16 | |
| G vs A | 2.20E-16 | ||
| GG vs AG + AA | 2.20E-16 | ||
| UC/1KGeno | AG + GG vs AA | 2.20E-16 | |
| G vs A | 2.20E-16 | ||
| GG vs AG + AA | 9.37E-09 | ||
| Cancer/Polyp | AG + GG vs AA | 0.7998 | |
| G vs A | 0.8036 | ||
| GG vs AG + AA | 1.0000 | ||
| Cancer/UC | AG + GG vs AA | 0.4362 | |
| G vs A | 0.4424 | ||
| GG vs AG + AA | 1.0000 | ||
| Polyp/UC | AG + GG vs AA | 0.3011 | |
| G vs A | 0.3096 | ||
| GG vs AG + AA | 1.0000 | ||
| rs6068816 C/T | Cancer/1KGeno | CT + TT vs CC | 2.20E-16 |
| T vs C | 2.20E-16 | ||
| TT vs CT + CC | 2.20E-16 | ||
| Polyp/1KGeno | CT + TT vs CC | 2.20E-16 | |
| T vs C | 2.20E-16 | ||
| TT vs CT + CC | 2.20E-16 | ||
| UC/1KGeno | CT + TT vs CC | 2.29E-09 | |
| T vs C | 2.20E-16 | ||
| TT vs CT + CC | 2.20E-16 | ||
| Cancer/Polyp | CT + TT vs CC | 1.0000 | |
| T vs C | 0.4635 | ||
| TT vs CT + CC | 0.4546 | ||
| Cancer/UC | CT + TT vs CC | 1.0000 | |
| T vs C | 0.2786 | ||
| TT vs CT + CC | 0.2658 | ||
| Polyp/UC | CT + TT vs CC | 1.0000 | |
| T vs C | 0.06703 | ||
| TT vs CT + CC | 0.06164 | ||
| rs6091822 G/T | Cancer/1KGeno | GT + TT vs GG | 2.20E-16 |
| T vs G | 1.06E-08 | ||
| TT vs GT + GG | 0.000472 | ||
| Polyp/1KGeno | GT + TT vs GG | 2.20E-16 | |
| T vs G | 4.06E-12 | ||
| TT vs GT + GG | 0.001364 | ||
| UC/1KGeno | GT + TT vs GG | 1.32E-13 | |
| T vs G | 2.40E-05 | ||
| TT vs GT + GG | 0.2411 | ||
| Cancer/Polyp | GT + TT vs GG | 1.0000 | |
| T vs G | 0.9258 | ||
| TT vs GT + GG | 0.5180 | ||
| Cancer/UC | GT + TT vs GG | 1.0000 | |
| T vs G | 0.8971 | ||
| TT vs GT + GG | 0.3094 | ||
| Polyp/UC | GT + TT vs GG | 1.0000 | |
| T vs G | 1.0000 | ||
| TT vs GT + GG | 0.5456 | ||
| rs8124792 G/A | Cancer/1KGeno | GA + AA vs GG | 2.20E-16 |
| A vs G | 2.20E-16 | ||
| AA vs GA + GG | 0.000758 | ||
| Polyp/1KGeno | GA + AA vs GG | 2.20E-16 | |
| A vs G | 2.20E-16 | ||
| AA vs GA + GG | 4.75E-05 | ||
| UC/1KGeno | GA + AA vs GG | 4.90E-09 | |
| A vs G | 2.91E-09 | ||
| AA vs GA + GG | 0.06359 | ||
| Cancer/Polyp | GA + AA vs GG | 1.0000 | |
| A vs G | 1.0000 | ||
| AA vs GA + GG | 1.0000 | ||
| Cancer/UC | GA + AA vs GG | 1.0000 | |
| A vs G | 1.0000 | ||
| AA vs GA + GG | 1.0000 | ||
| Polyp/UC | GA + AA vs GG | 1.0000 | |
| A vs G | 1.0000 | ||
| AA vs GA + GG | 1.0000 |
1KGeno: Control from 1000 Genomes Project; Cancer: Colon cancer cohort; MI: Minor allele (i.e., less common in controls); MJ: Major allele (i.e., more common in controls); Polyp: Colonic polyp cohort; UC: Ulcerative colitis cohort.