Table 3.
Associations between the selected single nucleotide polymorphisms and colon cancer, colonic polyp and ulcerative colitis, and odds ratio for the association of each polymorphism with these diseases
| Variable (MJ/Mia) | MAFa | HWE Pa | Cases/controls | Genetic model | P for χ2 test | Odds ratio for MI/MJ | 95%CI | |
| rs4809957 A/G | 0.393 | 0.476 | Cancer/1KGeno | G vs A | 2.50E-48 | 0.021 | 0.009 | 0.048 |
| Polyp/1KGeno | G vs A | 1.64E-64 | 0.026 | 0.014 | 0.048 | |||
| UC/1KGeno | G vs A | 1.57E-26 | 0.008 | 0.001 | 0.055 | |||
| rs6068816 C/T | 0.388 | 0.434 | Cancer/1KGeno | T vs C | 8.00E-47 | 32.086 | 16.238 | 63.403 |
| Polyp/1KGeno | T vs C | 8.72E-68 | 48.918 | 24.888 | 96.150 | |||
| UC/1KGeno | T vs C | 3.83E-22 | 18.260 | 8.350 | 39.932 | |||
| rs6091822 G/T | 0.284 | 0.208 | Cancer/1KGeno | T vs G | 3.72E-09 | 2.524 | 1.844 | 3.457 |
| Polyp/1KGeno | T vs G | 1.37E-12 | 2.596 | 1.984 | 3.395 | |||
| UC/1KGeno | T vs G | 0.00001 | 2.645 | 1.696 | 4.125 | |||
| rs8124792 G/A | 0.281 | 0.616 | Cancer/1KGeno | G vs A | 1.26E-13 | 0.083 | 0.036 | 0.188 |
| Polyp/1KGeno | G vs A | 2.93E-18 | 0.086 | 0.044 | 0.170 | |||
| UC/1KGeno | G vs A | 2.58E-07 | 0.062 | 0.015 | 0.256 | |||
a
MAF and HWE were calculated among controls only. 1KGeno: Control from 1000 Genomes Project; Cancer: Colon cancer cohort; MI: Minor allele (i.e., less common in controls); MJ: Major allele (i.e., more common in controls); Polyp: Colonic polyp cohort; UC: Ulcerative colitis cohort.