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. 2017 Jul 18;8:395–403. doi: 10.1016/j.omtn.2017.07.012

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© 2017 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

CRISPR/Cas9-Modified hAMSCs Are Effective against U87 Tumors in SCID Mice

(A) Overlay of bioluminescence and bright-field images of representative animals from each experimental group showing tumor growth development through time (arbitrary color palette ranging from blue = low intensity to red = high-intensity light emission). (B) Graph showing the median (solid line) of light emission intensity recorded from brain tumor areas and from individual animals (symbols) (n = 8). Arrows in the x axis indicate re-inoculation of therapeutic hAMSCs. (C) Kaplan-Meier graph illustrating survival curves for each experimental group. ***p < 0.001, EGFP-tTK-hAMSCs + GCV-treated group versus each control group.