Fig. 5.
Effect of RSV fusion inhibitors on RSV-induced lung pathology in neonatal lambs. a–f Gross a, c, e and microscopic b, d, f lung lesions on Day 6 post infection with RSV in vehicle-only-treated 1–3-day-old lambs of both sexes a, b in lambs that received once-daily dose of 25 mg kg−1 JNJ-53718678 c, d starting 24 h after infection, or in animals that received once-daily dose of 25 mg kg−1 JNJ-49214698 e, f starting 72 h after infection. Yellow arrows indicate RSV-induced gross lesions a. Blue arrow indicates the formation of a syncytium within bronchiolar epithelium that is somewhat thickened by hyperplasia b. Black arrow indicates a collapsed alveolus b. Yellow arrow indicates intraluminal neutrophils b. Black bars = 100 µm b, d, f