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. 2017 Jul 31;7:6955. doi: 10.1038/s41598-017-07196-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the gut microbiota composition in sham-, P. gingivalis-, and P. intermedia-administered mice by 16S rRNA sequencing. Analyses were carried out using faeces obtained before immunisation (day 35; (A and B)) and after induction of CIA (day 77; (C and D)). Relative abundances of each bacterial group at the phylum level before immunisation (day 35; A) and after induction of CIA (day 77; (C)) are indicated by box plots. *p < 0.05, **p < 0.01, One-way ANOVA with Bonferroni corrections for multiple comparisons. Box plot showing the relative abundance of the three bacterial genera found in treatment group before immunisation (day 35; B) and after induction of CIA (day 77; D). Bacteroides, Prevotella, and Allobaculum are represented as percentages on the Y-axis. *p < 0.05, **p < 0.01, One-way ANOVA with Bonferroni corrections for multiple comparisons.