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. 2017 Jul 31;7:6926. doi: 10.1038/s41598-017-07512-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TPPU administration attenuated Ang II-induced adventitial remodeling in C57BL/6 J mice. (A) Vessel sections were performed with hematoxylin and eosin staining, sirius red staining, and immunohistochemical staining of α-SMA and PCNA. (B) Quantitative analysis of adventitial thickness. (C) Quantitative analysis of adventitial α-SMA expression. (D) Quantitative analysis of adventitial PCNA expression. (E) Quantitative analysis of adventitial fibrosis. Data were expressed as Mean ± SEM, n = 8 mice for each group. *p < 0.05 vs. Vehicle, ^#p < 0.05 vs. Ang II.