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. 2017 Jul 31;7:6968. doi: 10.1038/s41598-017-05538-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical imaging and morphological features of the tumors (biopsies) of Patient 1. Two low-signal-intensity areas in the left temporal and occipital lobes and the ring-like peripheral edema are shown in non-enhanced (A) and corresponding enhanced T1-weighted MRI images (B). The lesions and edema are indicated by arrows. Calcification (indicated by arrows) was apparent in the occipital lesion under non-enhanced CT (C and D). (E) The sites of ten biopsies harvested from the surgical resection specimen are represented schematically on the MRI image. (F–O) Histologic specimens of the ten tumor samples stained with H&E.