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. 2017 Jul 31;7:6968. doi: 10.1038/s41598-017-05538-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution characteristics and heterogeneity of the TCR repertoires of Patient 1. (A) Cumulative size of the TOP250. The x-axis depicts the number of clones included (always starting from the most expanded clones). The y-axis shows the percentage of TCRB sequences that are covered by the included clones. (B) Frequencies of the ten most abundant common TCRB clones. The y-axis shows the percentage of the corresponding clone. The pairwise overlaps of the TOP250 among all samples are shown in (C). The boxplot of the overlaps of each sample with other samples according to the results from (C) is shown in (D). The pairwise overlaps of the TOP250 in one sample with the entire repertoire of the other samples are displayed in (E). The boxplot of the overlaps of each sample according to the results from (E) is shown in (F). Significant differences are marked by an asterisk (*).