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. 2017 Jul 31;7:6966. doi: 10.1038/s41598-017-07294-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Variations in the number of RGCs and correlations between the average escape latency and the number of RGCs or the b-wave. (A) Number of ganglion cells per 25x objective microscopic field in the retina was determined and is represented as a ratio between the IONC-operated eye and its sham control. Hypothermia greatly reduced the destruction of RGCs. Bars represent the mean ± SD of all samples (n = 16 animals per group). Asterisks represent statistically significant differences. ****p < 0.0001. (B) Correlation study between the escape latency as measured in the modified water maze and the number of RGCs per microscopic filed. A highly significant correlation was detected with animals having more RGCs taking shorter times to find the escape platform. (C) Correlation study between the escape latency and the modification in the b-wave pattern observed by electroretinography. A significant positive correlation was detected with animals taking longer to find the escape platform having a more irregular electrophysiological pattern.