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. 2017 Jul 31;7:6932. doi: 10.1038/s41598-017-07112-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hcy increases pSTAT3 expression in mitochondria. (A,B) Fluorescence immunohistochemistry for pSTAT3 and COX IV (a mitochondrial marker) 24 h following MCAO injury. Representative images of the mitochondrial marker COX IV (red) and STAT3 (green) staining in the DG region of the rat hippocampus and the cerebral ischemic cortex. Overlays demonstrate the colocalization of pSTAT3 and COX IV. Scale bars = 50 µm. (C,D) Quantitative assessment of pSTAT3/COX IV positive cells in the rat brain hippocampus and the cortex (n = 6/group, 10 fields/brain). (E) Representative western blot for pSTAT3. Bar graphs show semiquantitative levels of pSTAT3 as determined by band density analysis. n = 5 per group. *P < 0.05. The entire of membrane pictures of Fig. 4E were presented in the Supplementary Fig. S4.