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. 2017 Jul 31;7:6895. doi: 10.1038/s41598-017-07255-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of metabolite masses detected from pericyte cell extracts undergoing chondrogenesis (n ≥ 12). (A) Hierarchical cluster analysis of metabolic MS masses detected using LC-MS for pericytes cultured on planar substrates (undifferentiated) and cultured in Fmoc-F₂/S in the presence or absence of chondrogenic induction media 35 days. (B) Metabolites were mapped to metabolic pathways to ascertain which cell processes are significantly changed from the control. (C) Comparisons between Fmoc-F₂/S− and Fmoc-F₂/S+ isolate metabolite masses that differ between the two by more than two fold (inset) giving insight into processes that lead to the altered chondrocyte phenotype between Fmoc-F₂/S− and Fmoc-F₂/S+ Pathways marked with Ɨ were observed to be significantly different from undifferentiated cells but not between Fmoc-F₂/S− and Fmoc-F₂/S+ suggesting influence during chondrogenesis but do not contribute to the observed differences in chondrocyte phenotype.