Table 1.

List of GO terms enriched in expanded clones.

GO_Id	GO_name	Odds ratio	P-value	Q-value
GO:0050900	leukocyte migration	0.522	0.008	0.059
GO:0016570	histone modification	0.568	0.009	0.059
GO:0051276	chromosome organization	0.664	0.009	0.059
GO:0016568	chromatin modification	0.635	0.009	0.059
GO:0016569	covalent chromatin modification	0.571	0.009	0.059
GO:0006325	chromatin organization	0.651	0.012	0.065
GO:0045321	leukocyte activation	0.643	0.019	0.079
GO:0046649	lymphocyte activation	0.627	0.018	0.079
GO:0001775	cell activation	0.702	0.040	0.148

GO terms included in the Venn diagrams (Fig. 5D) were analyzed to determine statistical significance. P-value and Q-value was determined by using Fisher’s exact test or Storey Tibshirani method⁵², respectively. Odd ratio was calculated as S_PE_A/S_AE_P (S_P; number of singleton IS present nearby genes related to a specific GO term, S_A; number of singleton IS absent nearby those genes, E_P; number of expanded IS present nearby those genes, and E_A; number of expanded IS absent nearby those genes).