Table 1.
The characteristics of HNSCC cohort by HPV/P16 status.
| Characteristic | Value | HPV/P16 status | Pa | |||
|---|---|---|---|---|---|---|
| Positive (n = 50) | Negative (n = 32) | |||||
| N | (%) | N | (%) | |||
| Demographics | ||||||
| Age at diagnosis | Mean (years) | 61.5 | (95%CI: 58.9–64.2) | 65.5 | (95%CI: 60.9–70) | 0.14 |
| Gender | Male | 44 | (88) | 25 | (78) | 0.38 |
| Female | 6 | (12) | 7 | (22) | ||
| Tumour characteristics | ||||||
| Diagnosis | Squamous cell carcinoma | 49 | (98) | 30 | (94) | 0.28 |
| Other tumour types | 1 | (2) | 2 | (6) | ||
| Laterality | Right | 20 | (61) | 4 | (40) | 0.37 |
| Left | 12 | (36) | 6 | (60) | ||
| Not specified b | 17 | 22 | ||||
| Site of origin | Oropharynx | 42 | (89) | 14 | (48) | <0.01c |
| Skin | 2 | (4) | 3 | (10) | ||
| Larynx | 0 | (0) | 9 | (31) | ||
| Lip | 1 | (2) | 2 | (7) | ||
| Nasal cavity | 1 | (2) | 0 | (0) | ||
| Nasopharynx | 1 | (2) | 0 | (0) | ||
| Salivary gland | 0 | (0) | 1 | (3) | ||
| Not specified | 3 | 3 | ||||
| Recurrent disease | Yes | 20 | (43) | 14 | (45) | 1 |
| No | 26 | (57) | 17 | (55) | ||
| Not specified | 4 | 1 | ||||
| Anatomical stage | ||||||
| T category | T1 | 11 | (23) | 7 | (23) | 0.52 |
| T2 | 14 | (29) | 5 | (16) | ||
| T3 | 14 | (29) | 10 | (32) | ||
| T4 | 3 | (6) | 5 | (16) | ||
| Tx | 6 | (12) | 4 | (13) | ||
| Not specified | 2 | 1 | ||||
| N category | N0 | 10 | (21) | 11 | (35) | 0.35 |
| N1 | 9 | (19) | 6 | (19) | ||
| N2, nos | 3 | (6) | 1 | (3) | ||
| N2a | 7 | (15) | 1 | (3) | ||
| N2b | 11 | (23) | 7 | (23) | ||
| N2c | 7 | (15) | 2 | (6) | ||
| N3 | 0 | (0) | 1 | (3) | ||
| Nx | 1 | (2) | 2 | (6) | ||
| Not specified | 2 | 1 | ||||
| M category | M0 | 43 | (90) | 28 | (90) | 0.39 |
| M1 | 0 | (0) | 1 | (3) | ||
| Mx | 5 | (10) | 2 | (6) | ||
| Not specified | 2 | 1 | ||||
| TNM Stage (7th edition) | I | 2 | (4) | 5 | (17) | 0.17 |
| II | 2 | (4) | 2 | (7) | ||
| III | 13 | (27) | 7 | (23) | ||
| IV | 31 | (65) | 16 | (53) | ||
| Not specified | 2 | 2 | ||||
| Smoking status | ||||||
| Ever smoked | Yes | 22 | (56) | 20 | (74) | 0.23 |
| No | 17 | (44) | 7 | (26) | ||
| Not specified | 11 | 5 | ||||
| Smoking history | Median (pack-years) | 0 | (IQR: 0–27.5) | 25 | (IQR: 0–50) | 0.02 |
| Not specified | 19 | 8 | ||||
| Current smoker | Yes | 11 | (28) | 10 | (37) | 0.625 |
| No | 28 | (72) | 17 | (63) | ||
| Not specified | 11 | 5 | ||||
| Current amount | Median | 0 | (IQR: 0–0) | 10 | (IQR: 0–22.5) | 0.17 |
| Not specified | 28 | 17 | ||||
| Last smoked | Median (years ago) | 1.12 | (IQR: 0.812–3.19) | 21 | (IQR: 18.5–24) | 0.02 |
| Not specified | 50 | 26 | ||||
| Alcohol use | ||||||
| Ever consumed | Yes | 27 | (82) | 21 | (84) | 1 |
| No | 6 | (18) | 4 | (16) | ||
| Not specified | 17 | 7 | ||||
| Current drinker | Yes | 23 | (70) | 18 | (72) | 1 |
| No | 10 | (30) | 7 | (28) | ||
| Not specified | 17 | 7 | ||||
| Current amount | Median (grams/day) | 60 | (IQR: 20–80) | 40 | (IQR: 20–80) | 0.70 |
| Not specified | 23 | 11 | ||||
NB: IQR: Inter-quartile range; (a) Fisher’s exact test was used for hypothesis testing on categorical and binary data. Shapiro-Wilk test was used to determine the normality for numeric data. One-way Analysis of Variance (ANOVA) and Kruskal-Wallis tests were used to determine the difference between means (normally-distributed) and median (non-normally distributed) data respectively. (b) Significant between-group difference (p < 0.05) on the number of missing values (c) Statistically significant at α = 0.01.