Table 1. Characteristics of the survey participants.

Question	Response	N	%
Are you (N=79)
	Chief investigator	31	39
	Funder	1	1
	Other	14	18
	Statistician	30	38
	Trial manager	3	4
How long have you worked with dose-finding studies? (years) (N=78)
	0–2	10	13
	3–5	12	15
	6–10	12	15
	11–12	14	18
	20+	5	6
	New to topic	25	32
Have you ever been involved in a dose-finding study that, rather than using 3+3 or another rule-based design, used an alternative? (N=76)
	No	37	49
	Yes	37	49
	Don't know	2	3
Do you have access to software to support alternative approaches to 3+3 and other rule-based designs? Statisticians only (N=30)
	Don't know	6	20
	No	8	27
	Yes	16	53
Is appropriate statistical support available to you to undertake alternative approaches to 3+3 and other rule-based designs? Chief investigators only (N=30)
	Don't know	2	7
	No	3	10
	Yes	25	83
When designing a trial, how often do you consider alternatives to 3+3 and rule-based designs (N=77)
	Always	22	29
	Often	19	25
	Not very often	15	19
	Never	4	5
	Don't know	17	22