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. 2017 Jun 29;117(3):332–339. doi: 10.1038/bjc.2017.186

Table 3. Toxicity interval probabilities for all prespecified dose levels after one patient has been treated with 5 mg.

  Probability of toxicity rate in
 
Dose (mg) (0–0.16) Undertoxicity (0.16–0.33) Target toxicity (0.33–1) Overtoxicity Mean toxicity rate
0.2 0.889 0.065 0.046 0.056
0.5 0.860 0.075 0.065 0.071
1 0.828 0.089 0.083 0.086
2.5 0.770 0.115 0.115 0.112
5 0.717 0.128 0.155 0.140
10 0.649 0.144 0.207 0.177
20 0.559 0.163 0.278 0.228
40 0.439 0.186 0.374 0.300
80 0.301 0.179 0.520 0.403
120 0.231 0.167 0.601 0.473

Numbers in bold indicate safe, and those in italics indicate unsafe.