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Downregulation of MELK, NCAPG, BUB1, and CDK1 expression by miR-145-3p in PC3 and DU145 cells. (A–D) miR-145-3p binding sites in MELK mRNA. MELK mRNA expression 72 h after transfection with miR-145-3p. GUSB was used as an internal control. *P<0.0001. The bars indicate SDs. (E) The expression levels of miR-145-3p and target genes were negatively correlated in clinical PCa specimens.
