Table 1. Significantly downregulated miRNAs in CRPC.

miRNA	Locus	Log FC	FDR
CRPC vs non-PCa
miR-145-5p	5q32	−4.645	1.82E-31
miR-221-3p	Xp11.3	−4.220	6.96E-26
miR-31-5p	9p21.3	−6.354	1.89E-24
miR-145-3p	5q32	−3.930	8.42E-19
miR-143-5p	5q32	−4.198	3.94E-18
miR-222-3p	Xp11.3	−4.495	8.07E-18
miR-221-5p	Xp11.3	−3.769	3.03E-12
miR-143-3p	5q32	−3.010	1.02E-10
miR-125b-5p	11q24.1; 21q21.1	−3.234	1.48E-10
miR-150-5p	19q13.33	−3.454	1.75E-10
miR-6510-3p	17q12	−6.536	1.81E-10
miR-99a-5p	21q21.1	−2.790	7.83E-10
miR-100-5p	11q24.1	−3.157	4.32E-09
miR-204-5p	9q21.13	−4.540	2.11E-08
miR-205-5p	1q32.2	−8.408	2.89E-08
miR-187-3p	18q12.1	−4.257	3.35E-08
miR-1247-5p	14q32.31	−4.560	3.69E-08
miR-490-3p	7q33	−6.626	1.08E-07
miR-125b-1-3p	11q24.1	−2.774	1.90E-07
miR-27b-3p	9q22.33	−2.382	3.59E-07
miR-455-5p	9q33.1	−2.461	5.97E-07
miR-100-3p	11q24.1	−3.859	1.28E-05
miR-1271-5p	5q35.2	−2.082	1.37E-05
miR-328-3p	16q22.1	−2.112	1.55E-05
miR-196b-5p	7p15.2	−1.740	2.59E-05
miR-24-3p	9q22.33; 19p13.12	−1.699	5.98E-05
let-7c-3p	21q21.1	−4.152	6.34E-05
miR-184	15q25.1	−4.483	8.77E-05
miR-133a-5p	18q11.1; 20q13.33	−4.170	8.77E-05
miR-125b-2-3p	21q21.1	−2.145	8.77E-05
miR-873-5p	9p21.1	−3.599	0.000153
miR-9-5p	1q22; 5q14.3; 15q26.1	−2.006	0.000153
miR-504-5p	Xq26.3	−2.390	0.000185
miR-27b-5p	9q22.33	−2.251	0.000208
miR-3943	7p14.1	−4.655	0.000328
miR-548ba	2p16.3	−4.650	0.000431
miR-30e-3p	1p34.2	−1.524	0.000431
miR-214-3p	1q24.3	−1.859	0.000658
miR-125a-5p	19q13.41	−2.004	0.000681
miR-628-5p	15q21.3	−2.953	0.001013
miR-455-3p	9q33.1	−2.068	0.001769
miR-31-3p	9p21.3	−4.305	0.00182
miR-199a-5p	19p13.2; 1q24.3	−1.433	0.002757
miR-133a-3p	18q11.1; 20q13.33	−4.055	0.002817
miR-874-3p	5q31.2	−1.646	0.003569
miR-28-3p	3q28	−1.278	0.00539
miR-23b-3p	9q22.33	−1.773	0.005713
let-7e-3p	19q13.41	−1.874	0.006138
miR-889-3p	14q32.31	−1.878	0.007487
miR-142-5p	17q22	−1.503	0.007749
miR-452-3p	Xq28	−2.343	0.007917
miR-199b-5p	9q34.12	−1.839	0.008345
miR-452-5p	Xq28	−1.670	0.009339
miR-1260b	11q21	−1.873	0.010403
miR-139-5p	11q13.4	−1.411	0.013082
miR-205-3p	1q32.2	−4.128	0.01419
miR-224-5p	Xq28	−1.642	0.014227
miR-23a-3p	19p13.12	−1.072	0.014881
miR-199b-3p	9q34.12	−1.488	0.016875
miR-199a-3p	19p13.2; 1q24.3	−1.488	0.016905
miR-1269a	4q13.2	−4.294	0.017298
miR-944	3q28	−2.426	0.017298
miR-136-5p	14q32.31	−1.714	0.018059
miR-4634	5q35.2	−1.960	0.018527
miR-224-3p	Xq28	−2.339	0.03156
miR-6511b-3p	16p13.3; 16p13.11	−2.237	0.03156
let-7c-5p	21q21.1	−1.701	0.035011
miR-887-3p	5p15.1	−1.345	0.035011
miR-1260a	14q24.3	−2.617	0.035037
miR-1247-3p	14q32.31	−2.996	0.03528
miR-1298-5p	Xq23	−3.686	0.036895
miR-101-5p	1p31.3	−1.598	0.039947
miR-222-5p	Xp11.3	−3.853	0.043768
miR-656-3p	14q32.31	−2.760	0.044013
miR-181c-5p	19p13.12	−1.622	0.045462
miR-214-5p	1q24.3	−1.373	0.047573
CRPC vs HSPC
miR-145-5p	5q32	−3.140	1.70E-05
miR-125b-5p	11q24.1; 21q21.1	−2.800	7.28E-05
miR-1247-5p	14q32.31	−4.369	7.54E-05
miR-143-5p	5q32	−3.181	7.54E-05
miR-145-3p	5q32	−2.876	1.95E-04
miR-31-5p	9p21.3	−6.095	4.08E-04
miR-150-5p	19q13.33	−3.906	7.55E-04
miR-221-3p	Xp11.3	−2.534	7.55E-04
miR-143-3p	5q32	−2.624	1.39E-03
miR-490-3p	7q33	−6.969	2.41E-03
miR-3943	7p14.1	−4.750	3.08E-03
miR-9-5p	1q22; 5q14.3; 15q26.1	−5.457	3.87E-03
miR-100-3p	11q24.1	−3.618	4.19E-03
miR-100-5p	11q24.1	−2.442	4.19E-03
miR-196b-5p	7p15.2	−2.027	4.57E-03
miR-125b-1-3p	11q24.1	−2.728	4.93E-03
miR-99a-5p	21q21.1	−2.097	4.93E-03
let-7c-3p	21q21.1	−3.956	5.91E-03
miR-222-3p	Xp11.3	−2.311	6.28E-03
miR-221-5p	Xp11.3	−2.562	7.24E-03
miR-9-3p	1q22; 5q14.3; 15q26.1	−5.538	1.22E-02
miR-27a-5p	19p13.12	−3.290	1.22E-02
miR-125b-2-3p	21q21.1	−2.107	1.41E-02
miR-27b-3p	9q22.33	−1.790	1.69E-02
miR-142-5p	17q22	−2.176	2.26E-02
miR-1260b	11q21	−2.482	2.30E-02
miR-214-3p	1q24.3	−1.811	3.02E-02
miR-671-3p	7q36.1	−1.868	3.35E-02
miR-205-5p	1q32.2	−4.450	4.96E-02
miR-199b-5p	9q34.12	−2.022	4.96E-02

Abbreviations: FC=fold change; FDR=false discovery rate.