Table 3.

Interaction results between rs9939609 risk allele and depression on log₁₀(BMI) in the five independent studies and fixed effects, random effects and Han/Eskin model meta-analyses

		Interaction
	n	β	s.e.	P
Study
Radiant	3251	0.18	0.06	0.002
PsyCoLaus	2994	0.12	0.05	0.034
GSK	1677	−0.09	0.07	0.168
MARS	1116	0.26	0.15	0.083
NESDA/NTR	4663	0.19	0.04	3.2 × 10−6
Meta-analysis
Fixed effects
Replication studiesa	7456	0.12	0.03	2.7 × 10−4
Replication studies (no GSK)	5779	0.19	0.04	6.6 × 10−7
All studies	13 701	0.13	0.03	3.1 × 10−7
All studies (no GSK)	12 024	0.17	0.03	1.1 × 10−9
Random effects
Replication studiesa	7456	0.10	0.11	0.35
Replication studies (no GSK)	5779	0.19	0.04	6.6 × 10−7
All studies	13 701	0.12	0.05	0.02
All studies (no GSK)	12 024	0.17	0.03	1.110−9
Han/Eskin model
Replication studiesa	7456	0.10	0.11	1.410−5
Replication studies (no GSK)	5779	0.19	0.04	7.910−7
All studies	13 701	0.12	0.05	6.910−8
All studies (no GSK)	12 024	0.17	0.03	1.710−9
Meta-analysis
Replication studies	7456	85.3b	13.614c	0.001d
Replication studies (no GSK)	5779	0	0.221c	0.638d
All studies	13 701	72.6b	14.608c	0.006d
All studies (no GSK)	12 024	0	1.828c	0.609d

BMI, body mass index; GSK, GlaxoSmithKline study; MARS, Munich Antidepressant Response Signature project; NESDA/NTR, Netherlands Study of Depression and Anxiety/Netherlands Twin Register.

^a.Replication studies: GSK, MARS and NESDA/NTR.

^b.I² statistic.

^c.Q statistic.

^d.P-value of Q.