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. 2017 Aug;58(8):1216–1223. doi: 10.2967/jnumed.116.173179

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© 2017 by the Society of Nuclear Medicine and Molecular Imaging.

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FIGURE 3. — ¹¹C-sarcosine and ¹¹C-choline small-animal PET. Improved visualization of a DU-145 tumor (white arrows) and lower hepatic uptake (blue arrows) after intravenous injection of 16.3 MBq of ¹¹C-sarcosine (C and D) compared with 16.8 MBq of ¹¹C-choline (A and C) on transaxial (A and C) and coronal (B and D) small-animal PET images (summed data 5–20 min; SUV range, 0–4). Both tracers display intense renal uptake (red arrows). Brain uptake (yellow arrows) is essentially absent for ¹¹C-sarcosine, whereas ¹¹C-choline brain uptake is low. Cumulative exhaled mean (±SD) radioactivity (as % injected dose) representing ¹¹C-CO₂ (E) was measured in healthy rats after intravenous injection of ¹¹C-sarcosine (●), ¹¹C-acetate (○), and ¹¹C-choline (▼).