Table 1. Studies from the Female Lung Cancer Consortium in Asia (FLCCA) that participated in a gene-environment interaction analysis of GWAS-identified SNPs that confer risk of never smoking lung cancer and household air pollution.
| Genetic Epidemiological Study of Lung Adenocarcinoma (GELAC) | Shenyang Lung Cancer Study (SLCS) | Shanghai Women's Health Cohort Study (SWHS) | All Studies | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |||||||||
|
| ||||||||||||||||
| N | % | N | % | N | % | N | % | N | % | N | % | N | % | N | % | |
| Total Subjects | 1098 | 100% | 1019 | 100% | 549 | 100% | 260 | 100% | 84 | 100% | 70 | 100% | 1731 | 100% | 1349 | 100% |
| Age* | ||||||||||||||||
| <59 | 504 | 45.9% | 479 | 47.0% | 282 | 51.4% | 127 | 48.8% | 40 | 47.6% | 31 | 44.3% | 826 | 47.7% | 637 | 47.2% |
| >=59 | 594 | 54.1% | 540 | 53.0% | 267 | 48.6% | 133 | 51.2% | 44 | 52.4% | 39 | 55.7% | 905 | 52.3% | 712 | 52.8% |
| Solid Fuel Use | ||||||||||||||||
| Ever | 314 | 28.6% | 251 | 24.6% | 311 | 56.6% | 130 | 50.0% | 43 | 51.2% | 42 | 60.0% | 668 | 38.6% | 423 | 31.4% |
| Never | 784 | 71.4% | 768 | 75.4% | 238 | 43.4% | 130 | 50.0% | 41 | 48.8% | 28 | 40.0% | 1063 | 61.4% | 926 | 68.6% |
| Coal Use | ||||||||||||||||
| Ever | 69 | 6.3% | 46 | 4.5% | 58 | 10.6% | 100 | 38.5% | 43 | 51.2% | 42 | 60.0% | 365 | 21.1% | 188 | 13.9% |
| Never | 784 | 71.4% | 768 | 75.4% | 253 | 46.1% | 130 | 50.0% | 41 | 48.8% | 28 | 40.0% | 1063 | 61.4% | 926 | 68.6% |
| Environmental Tobacco Smoke | ||||||||||||||||
| Ever | 767 | 69.9% | 615 | 60.4% | 481 | 87.6% | 222 | 85.4% | 59 | 70.2% | 53 | 75.7% | 1307 | 75.5% | 890 | 66.0% |
| Never | 293 | 26.7% | 382 | 37.5% | 59 | 10.7% | 35 | 13.5% | 16 | 19.0% | 11 | 15.7% | 368 | 21.3% | 428 | 31.7% |
| rs7086803 | ||||||||||||||||
| GG | 461 | 42.0% | 488 | 47.9% | 269 | 49.0% | 143 | 55.0% | 33 | 39.3% | 44 | 62.9% | 763 | 44.1% | 675 | 50.0% |
| GA | 459 | 41.8% | 415 | 40.7% | 239 | 43.5% | 105 | 40.4% | 38 | 45.2% | 21 | 30.0% | 736 | 42.5% | 541 | 40.1% |
| AA | 128 | 11.7% | 66 | 6.5% | 41 | 7.5% | 12 | 4.6% | 13 | 15.5% | 5 | 7.1% | 182 | 10.5% | 83 | 6.2% |
| rs9387478 | ||||||||||||||||
| AA | 240 | 21.9% | 274 | 26.9% | 111 | 20.2% | 58 | 22.3% | 12 | 14.3% | 19 | 27.1% | 363 | 21.0% | 351 | 26.0% |
| AC | 548 | 49.9% | 518 | 50.8% | 281 | 51.2% | 135 | 51.9% | 39 | 46.4% | 38 | 54.3% | 868 | 50.1% | 691 | 51.2% |
| CC | 310 | 28.2% | 227 | 22.3% | 157 | 28.6% | 67 | 25.8% | 33 | 39.3% | 13 | 18.6% | 500 | 28.9% | 307 | 22.8% |
| rs2395185 | ||||||||||||||||
| GG | 435 | 39.6% | 475 | 46.6% | 226 | 41.2% | 102 | 39.2% | 32 | 38.1% | 32 | 45.7% | 693 | 40.0% | 609 | 45.1% |
| GT | 515 | 46.9% | 440 | 43.2% | 258 | 47.0% | 126 | 48.5% | 39 | 46.4% | 33 | 47.1% | 812 | 46.9% | 599 | 44.4% |
| TT | 148 | 13.5% | 104 | 10.2% | 65 | 11.8% | 32 | 12.3% | 13 | 15.5% | 5 | 7.1% | 226 | 13.1% | 141 | 10.5% |
| rs4488809(rs4600802) | ||||||||||||||||
| TT | 266 | 24.2% | 291 | 28.6% | 177 | 32.2% | 84 | 32.3% | 22 | 26.2% | 24 | 34.3% | 465 | 26.9% | 399 | 29.6% |
| TC | 506 | 46.1% | 500 | 49.1% | 274 | 49.9% | 130 | 50.0% | 44 | 52.4% | 41 | 58.6% | 824 | 47.6% | 671 | 49.7% |
| CC | 275 | 25.0% | 178 | 17.5% | 98 | 17.9% | 46 | 17.7% | 18 | 21.4% | 5 | 7.1% | 391 | 22.6% | 229 | 17.0% |
| rs2736100 | ||||||||||||||||
| TT | 265 | 24.1% | 394 | 38.7% | 164 | 29.9% | 93 | 35.8% | 18 | 21.4% | 21 | 30.0% | 447 | 25.8% | 508 | 37.7% |
| TG | 592 | 53.9% | 481 | 47.2% | 271 | 49.4% | 123 | 47.3% | 46 | 54.8% | 42 | 60.0% | 909 | 52.5% | 646 | 47.9% |
| GG | 240 | 21.9% | 144 | 14.1% | 114 | 20.8% | 44 | 16.9% | 20 | 23.8% | 7 | 10.0% | 374 | 21.6% | 195 | 14.5% |
*
based on the median age of controls in all studies