Table 2. Five GWAS-identified SNPs that confer risk of never smoking lung cancer and gene-household air pollution interaction analyses by exposure type.
| SNP | Chromosome | Gene | All Lung Cancer Cases (N = 1,731) | |
|---|---|---|---|---|
|
| ||||
| Solid Fuel Interaction | Coal Interaction | |||
|
| ||||
| p-value* | p-value* | |||
| rs7086803 | 10 | VTI1A | 0.49 | 0.90 |
| rs9387478 | 6 | GOPC | 0.05 | 0.35 |
| rs2395185 | 6 | HLA Class II | 0.08 | 0.02 |
| rs4488809† | 3 | TP63 | 0.07 | 0.04 |
| rs2736100 | 5 | TERT,hTERT | 0.90 | 0.82 |
rs4488809(rs4600802); bold highlights indicate p≤0.05;
adjusted for age and study