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. 2017 Jun 6;7(6):e1148. doi: 10.1038/tp.2017.113

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Repressor element 1-silencing transcription (REST) values stratified by clinical diagnosis. Log₁₀-transformed REST values (corrected for assay plate and center) are represented as means (s.e.m. error bars). (a) There was a significant decline in REST from healthy elderly controls (HEC) to mild cognitive impairment (MCI) to Alzheimer’s disease (AD). Compared with the AD group, the MCI group showed significantly higher levels of REST (+95.73, 95% CI 1.82–189.65, P=0.046) as did the control group (+122.45, 95% CI 27.96–216.93, P=0.011). (b) Dividing mild cognitive impairment groups into those who remained stable (sMCI) and those who later converted to AD (cMCI), compared with the AD group, REST levels were not significantly different in the cMCI group (26.00, 95% CI −90.67–142.68, P=0.66) but were significantly higher in the sMCI group (159.06, 95% CI 47.77–270.65, P=0.005) and controls (126.12, 95% CI 32.53–219.70, P=0.008).