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The organization of the classical swine fever virus (CSFV) genome and the encoding proteins. The positive-sense, single-stranded RNA genome of 12.3 kb contains 5′- and 3′-noncoding regions (NCRs) important for viral RNA replication and/or protein translation and a large open reading frame (ORF) that encodes a large polyprotein. The polyprotein is processed into four structural proteins and eight nonstructural proteins by a combination of viral and cellular proteases.
