Table 1.
Characteristics of Hepatitis B and Delta Viruses.
| Hepatitis B Virus (HBV) | Hepatitis Delta Virus (HDV) | |
|---|---|---|
|
Family
Genus |
Hepadnaviridae Orthohepadnaviruses |
Unassigned Deltavirus |
| Genome | relaxed circular partially double-stranded DNA ca. 3.2 kbp | single-stranded (−) RNA 1.7 kb |
| Virus-Encoded Proteins | HBcAg, HBeAg, pol, HBx, L-/M-/S-HBsAg | L-/S-HDAg |
| Cellular Receptors | HSPG, hNTCP | HSPG, hNTCP |
| Chronically Infected Individuals Worldwide | 240 million | 15–20 million (co-infected with HBV) |
| Vaccine Available | Yes | HBV vaccine |
| Curative Therapy Available | No | No |
HBcAg: Hepatitis B core antigen; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen; pol: polymerase; HBx: Hepatitis B x protein; HDAg: Hepatitis Delta antigen; HSPG: heparan sulfate proteoglycan; hNTCP: human sodium taurocholate cotransporting polypeptide.