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Overview of the three novel antiviral drugs in clinical phase II development.
| Drug | Target | Mechanism | Clinical Trial Identifier(s) | Company |
|---|---|---|---|---|
| Lonafarnib | Farnesyl transferase | Assembly inhibition |
NCT02430181 NCT02430194 |
Eiger Bio (Palo Alto, CA, USA) |
| Nucleic acid polymers | HBsAg? | HDV release inhibition? |
NCT02233075 NCT02876419 |
Replicor (Montreal, QC, Canada) |
| Myrcludex B | hNTCP | Entry inhibition | NCT02637999 | Myr GmbH (Burgwedel, NI, Germany) |
