Figure 3.

Distribution of candidate STn‐expressing glycoproteins in muscle‐invasive bladder tumours (detailed in Table S2) comprehensively integrated according to cellular localization (A), molecular (B) and cell functions (C) based on gene ontology analysis by Panther bioinformatics tool. STn‐expressing proteins were found to be associated with a wide array of molecular and biological functions as depicted in detail in the figure. Accordingly, the identified glycoproteins were involved in nine main classes of molecular functions, with an overrepresentation of catalytic activities (hydrolase, lyase and transferase activities) and protein binding mediation. Moreover, 13 main biological functions were highlighted, being the most representative cellular processes such as cell communication and, to some extent, cell cycle control. These observations suggest that altered glycosylation may influence a wide range of key cell events, which warrants evaluation in future studies.