Table 1.

List of miRNAs located in the regions with genomic amplification, their regulation in GBM and the relevant information of their host gene

S.No	miRNA	Region hg19	TCGA		Lab Dataa		Host gene
			Diff. LFCb	Adj. P (Benjamini–Hochberg)	Diff. LFCb	P‐value	Gene	Diff. LFCb	Adj. P (Benjamini–Hochberg)
1	hsa‐miR‐339	chr7:229794‐12384994	1.10	0.000004	NA	NA	C7orf50	0.20	0.294596
2	hsa‐miR‐93	chr7:97568276‐100324915	1.49	0.000002	2.03	0.000000	MCM7	0.96	0.000004
3	hsa‐miR‐106b	chr7:97568276‐100324915	1.87	0.000002	2.36	0.000000	MCM7	0.96	0.000004
4	hsa‐miR‐25	chr7:97568276‐100324915	1.90	0.000002	2.23	0.000000	MCM7	0.96	0.000004
5	hsa‐miR‐3125	chr2:12061625‐20964134	NA	NA	NA	NA	TRIB2	1.20	0.000176
6	hsa‐miR‐4648	chr7:229794‐12384994	NA	NA	NA	NA	LFNG	1.17	0.000328
7	hsa‐miR‐3609	chr7:97568276‐100324915	NA	NA	NA	NA	TRRAP	0.68	0.000217
8	hsa‐miR‐3973	chr11:32434754‐37349348	NA	NA	NA	NA	LDLRAD3	1.52	0.000002
9	hsa‐miR‐26a‐2	chr12:58075399‐58311523	NA	NA	NA	NA	CTDSP2	0.91	0.000046
10	hsa‐miR‐4745	chr19:113418‐2800481	NA	NA	NA	NA	PTBP1	1.50	0.000002
11	hsa‐miR‐199a‐1	chr19:10070230‐11643726	NA	NA	NA	NA	DNM2	0.92	0.000003
12	hsa‐miR‐4748	chr19:10070230‐11643726	NA	NA	NA	NA	DNM2	0.92	0.000003
13	hsa‐miR‐638	chr19:10070230‐11643726	0.22	0.597781	−1.69	0.002120	DNM2	0.92	0.000003
14	hsa‐miR‐3189	chr19:18148615‐19986025	NA	NA	NA	NA	GDF15	1.79	0.000020
15	hsa‐miR‐640	chr19:18148615‐19986025	0.15	0.000243	0.30	0.686010	GATAD2A	0.98	0.000005
16	hsa‐miR‐643	chr19:52589104‐54795358	0.03	0.002225	NA	NA	ZNF766	0.65	0.009546
17	hsa‐miR‐4754	chr19:56623806‐59092515	NA	NA	NA	NA	RPS5	0.92	0.000116

^a Lab Data: Genome‐wide expression profiling identifies deregulated miRNAs in malignant astrocytoma (Rao et al., 2010).

^b Diff LFC: differential log₂ fold change (GBM minus control brain).