Table 2.
List of miRNAs located in the regions with genomic deletions and their regulation in GBM and the relevant information of their host gene
| S.No | miRNA | Region hg19 | TCGA | Lab Dataa | Host gene | ||||
|---|---|---|---|---|---|---|---|---|---|
| Diff. LFCb | Adj. P (Benjamini–Hochberg) | Diff. LFCb | P‐value | Gene | Diff. LFCb | Adj. P (Benjamini–Hochberg) | |||
| 1 | hsa‐miR‐134 | chr14:101464256‐102072149 | −0.59 | 0.000088 | 0.42 | 0.287537 | NA | NA | NA |
| 2 | hsa‐miR‐154 | chr14:101464256‐102072149 | −0.71 | 0.000002 | NA | NA | NA | NA | NA |
| 3 | hsa‐miR‐323 | chr14:101464256‐102072149 | −1.41 | 0.000002 | NA | NA | NA | NA | NA |
| 4 | hsa‐miR‐377 | chr14:101464256‐102072149 | −1.51 | 0.000003 | 0.08 | 0.739883 | NA | NA | NA |
| 5 | hsa‐miR‐379 | chr14:101464256‐102072149 | −1.88 | 0.000002 | −0.33 | 0.230623 | NA | NA | NA |
| 6 | hsa‐miR‐381 | chr14:101464256‐102072149 | −1.11 | 0.000002 | 0.44 | 0.001586 | MIR381HG | NA | NA |
| 7 | hsa‐miR‐410 | chr14:101464256‐102072149 | −2.20 | 0.000002 | −2.00 | 0.000006 | NA | NA | NA |
| 8 | hsa‐miR‐411 | chr14:101464256‐102072149 | −1.03 | 0.000002 | −0.03 | 0.889330 | NA | NA | NA |
| 9 | hsa‐miR‐487a | chr14:101464256‐102072149 | −0.64 | 0.000020 | −0.25 | 0.209734 | NA | NA | NA |
| 10 | hsa‐miR‐487b | chr14:101464256‐102072149 | −0.95 | 0.000008 | −0.40 | 0.236795 | MIR381HG | NA | NA |
| 11 | hsa‐miR‐758 | chr14:101464256‐102072149 | −0.87 | 0.000002 | NA | NA | NA | NA | NA |
| 12 | hsa‐miR‐495 | chr14:101464256‐102072149 | −0.53 | 0.000002 | −0.65 | 0.005893 | NA | NA | NA |
| 13 | hsa‐miR‐2681 | chr13:79820643‐115105760 | NA | NA | NA | NA | FGF14 | −1.34 | 0.010560 |
| 14 | hsa‐miR‐4705 | chr13:79820643‐115105760 | NA | NA | NA | NA | FGF14 | −1.34 | 0.010560 |
| 15 | hsa‐miR‐1233‐1 | chr15:33089320‐41016345 | NA | NA | NA | NA | GOLGA8A | −1.15 | 0.002720 |
| 16 | hsa‐miR‐1233‐2 | chr15:33089320‐41016345 | NA | NA | NA | NA |
GOLGA8A ;GOLGA8B |
−1.15 | 0.002720 |
| 17 | hsa‐miR‐1286 | chr22:16124218‐20311704 | NA | NA | NA | NA | RTN4R | −3.55 | 0.000002 |
| 18 | hsa‐miR‐3944 | chr10:127622813‐135506681 | NA | NA | NA | NA | ECHS1 | −0.93 | 0.000002 |
| 19 | hsa‐miR‐4296 | chr10:127622813‐135506681 | NA | NA | NA | NA | CTBP2 | −0.61 | 0.000027 |
| 20 | hsa‐miR‐4484 | chr10:127622813‐135506681 | NA | NA | NA | NA | UROS | −1.50 | 0.000004 |
| 21 | hsa‐miR‐4501 | chr13:79820643‐115105760 | NA | NA | NA | NA | HS6ST3 | −3.65 | 0.000002 |
| 22 | hsa‐miR‐4535 | chr22:42957116‐51218950 | NA | NA | NA | NA | FAM19A5 | −1.27 | 0.000002 |
| 23 | hsa‐miR‐4762 | chr22:42957116‐51218950 | NA | NA | NA | NA | ATXN10 | −0.70 | 0.000010 |
| 24 | hsa‐miR‐648 | chr22:16124218‐20311704 | 0.19 | 0.031338 | NA | NA | MICAL3 | −0.94 | 0.000021 |
a Lab Data: Genome‐wide expression profiling identifies deregulated miRNAs in malignant astrocytoma (Rao et al., 2010).
b Diff LFC: differential log2 fold change (GBM minus control brain).