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Belinostat induces acetylation of histone H3 and downregulates MAPK pathway progressively. Kinetic studies of belinostat (PXD101) treatment (1 μm) were performed over 72 h (6, 12, 24, 36, 48, 72 h) in Calu‐1 and H520 cells. The effects on acetylated histone H3, SOS1, SOS2, ERK, and p38 were evaluated with immunoblotting. β‐Actin shown as loading control.
