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. 2017 May 30;11(8):965–980. doi: 10.1002/1878-0261.12064

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© 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Ubiquitin‐related genes, but not SOS 1 and 2, are transcriptionally regulated by belinostat in lung squamous cell carcinoma (SCC) cells. (A) Real‐time quantitative PCR (qPCR) was conducted to quantify the mRNA expression of SOS1 and SOS2 after vehicle or belinostat (PXD101) (1 μm) treatment. Data were represented as average relative quantification ± SD (n = 3). (B) Heat map represents the gene expression of altered genes (fold change > 1.5) identified by Affymetrix microarrays across all lung SCC cells (H596, H1869, H226, and ChaGo‐k‐1, Calu‐1, H2170, SW900, and H2066) treated with belinostat at respective IC ₅₀. Consistently upregulated genes were highlighted in red, and downregulated genes in green. (C) Expressions of both SOS1 and SOS2 from the same array were tabulated in the bar chart as average fold regulation ± SD.