Table 3.

Significant pathways associated with treatment with everolimus plus AZA by SPIA in MZ‐CRC‐1 cells

Pathway name	pPERT	pNDE	pGFdr
PI3K‐Akt signaling pathway	0.102	0.0002	0.0178
Neurotrophin signaling pathway	0.689	0.0002	0.0308
ECM/receptor interaction	0.115	0.0013	0.0308
Focal adhesion	0.199	0.0018	0.0415

pPERT, probability of observing a total accumulated perturbation of the pathway more extreme than expected by chance; pNDE, probability of obtaining a number of DEGs in the given pathway at least as large as the observed one; pGFdr, false discovery rate for the global P‐value from the combination of pPERT and pNDE.