Table 4.
Path | Type of process | Control | Everolimus + AZA | Difference | |||
---|---|---|---|---|---|---|---|
Estimate | P value | Estimate | P value | Estimate | P value | ||
MDM2→TP53 | Inhibition | 0.8271 | 0.0001 | −0.9864 | 0.0022 | −1.8135 | 0.0000 |
NGFR→ARHGDIB | Binding/association | 0.8935 | 0.0001 | 2.7208 | 0.0001 | 1.8273 | 0.0125 |
EPHA2→IRS1 | Activation | −0.5077 | 0.0079 | 0.3521 | 0.2699 | 0.8598 | 0.0208 |
PIP5K1C→VCL | Indirect | −0.6464 | 0.0237 | 0.3072 | 0.0001 | 0.9536 | 0.0013 |
VCL→ACTN1 | Binding/association | −0.0985 | 0.8827 | 2.4853 | 0.0002 | 2.5839 | 0.0062 |
ITGA1→PTK2 | Binding | −0.3282 | 0.0206 | 0.1908 | 0.2790 | 0.5190 | 0.0218 |
NGFR→RAC1 | Activation | −0.9042 | 0.0180 | 0.5223 | 0.0155 | 1.4265 | 0.0012 |
RAC1→MAPK10 | Indirect | 0.0499 | 0.6359 | 0.5799 | 0.0001 | 0.5300 | 0.0033 |
NGFR→CDC42 | Activation | 0.2736 | 0.3068 | −1.0567 | 0.0001 | −1.3303 | 0.0004 |
PAK1→MAP2K1 | Phosphorylation | 0.4008 | 0.0018 | −0.0669 | 0.0998 | −0.4678 | 0.0005 |