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. 2017 Jun 5;11(8):1078–1098. doi: 10.1002/1878-0261.12076

Figure 1.

Figure 1

Dovitinib reduced STAT3, Lin28, and HMGA2. (A) Western blot analysis showed the downregulation of Let‐7 binding protein LIN28A upon Dov treatment (5 μm) at 48 h and 72 h in U251. (B) The number of tumor spheres with ≥50 μm diameter progressively declined with increasing Dov concentrations (3–5 μm) to reach less than 50% at 5 μm Dov, shown here for U87MG cells. (C) Dov concentrations at 1, 2, and 5 μm for 24 h, 48 h, and 72 h revealed a selective downregulation of the stem cell factor HMGA2 and pSTAT3 at Tyr705 and an increase in γH2AX shown here for U251 and GB‐10 cells. Total STAT3 remained unchanged and β‐actin served as loading control. **P < 0.01; *P < 0.05.